2例糖尿病患者颈动脉内膜中层厚度的相关因素分析  

Factor analysis of carotid intima-media thickness in type 2 diabetics

作　　者：齐晓玲[1] 徐礼五[1] 王郭伟[1] 余洋[1] 段成[1] 袁玲[1] 王江宁[1] 刘智[1] 

机构地区：[1]淮南市第一人民医院内分泌肾病科,232007

出　　处：《安徽医学》2008年第3期284-286,共3页Anhui Medical Journal

摘　　要：目的探讨2型糖尿病患者颈动脉内膜中层厚度的相关因素。方法将91例2型糖尿病患者根据颈动脉内膜中层厚度分为颈动脉内膜正常组(IMT<1.0mm)、颈动脉内膜增厚组(IMT≥1.0mm)组,分别检测各组血清C反应蛋白(CRP)、空腹血糖(FBG)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、血浆致动脉硬化指数(AIP)、血尿酸(UA)并记录年龄、糖尿病病程、体重指数(BMI)、收缩压(SBP)、舒张压(DBP)、脉压、吸烟史、高血压史、微血管并发症斑块形成等指标,并进行统计学处理。结果颈动脉内膜增厚组中年龄、TG、AIP、UA、CRP值以及斑块形成、微血管并发症发生率均比颈动脉内膜正常者组显著增高,差异均有统计学意义。Logistic回归分析显示,以IMT为应变量先后入选的变量有年龄(P<0.01)、甘油三酯(P<0.05)。结论2型糖尿病患者颈动脉内膜增厚与年龄、TG、AIP、UA、CRP等多因素有关,尤其与年龄、TG密切相关。Objective To discuss the correlation factor of carotid intima - media thickness in the patients with type 2 diabetes mellitus. Methods 91 patients with T2DM, including normal carotid intima - media and thickening carotid intima - media were studied. The physical examinations including measurement of age, diabetes course, body mass index （BMI） , blood pressure （SBP and DBP） , smnking history, hypertension history, microangiopathy, artery plaque formation etc. Laboratory tests included. serum c - reactive protein （ CRP）, fasting blood glucose（ FPG）, total cholesterol（ TC）, tfiglycefides（ TC）, HDL - C, LDL - C, atherogenieindexofplasma （AIP） and uric acid. Results The levels of serum TG, AIP, UA, CRP, age and incidence rate of plaque formation microangiopathy in carotid intima - media thickening group were higher than those in normal carotid intima - media group. Stepwise regression analysis of relative factors for carotid intima - media thickness showed that the value of age （ P 〈 0.01 ） and triglyceride （ P 〈 0.05 ） were significantly associated with the carotid intima - media thickness. Conclusion Carotid intima - media thickness may be related to age,TC,AIP,UA and CRP in the patients with type 2 diabetes mellitus,especially to age and TC .

关 键 词：糖尿病 颈动脉内膜中层厚度 动脉粥样硬化 

分 类 号：R587.1[医药卫生—内分泌]