流动注射-化学发光法测定片剂中左炔诺孕酮含量  

FI-Chemiluminescence Determination of Levonorgestrol in Its Tablets

作　　者：张淑琼[1] 何树华[1] 

机构地区：[1]涪陵师范学院化环系,重庆408003

出　　处：《理化检验（化学分册）》2008年第5期467-468,共2页Physical Testing and Chemical Analysis(Part B:Chemical Analysis)

基　　金：重庆市教委科学研究项目(041304)

摘　　要：在酸性条件下，高锰酸钾与亚硫酸钠能够产生较弱的化学发光，而左炔诺孕酮能够增强该化学发光强度。在一定浓度范围内，增加的发光强度与左炔诺孕酮的浓度呈线性关系，由此建立了一种测定左炔诺孕酮的流动注射化学发光方法。方法的检出限（S／N=3）为6．4μg·L^-1，线性范围为0．01～0．5mg·L^1-和0．5～5．0mg·L^-1，对0．1mg·L^-1左炔诺孕酮平行测定11次，其相对标准偏差为4.3％。In a dil. H2SO4 medium, weak chemiluminescence （CL） was produced by the reaction between KMnO4 and Na2SO3, and was enhanced to a great extent by the presence of levonorgestrol （abbreviated as LNGT）. It was found that in the concentration ranges of 0. 01 to 0. 5 mg · L^-1 and 0. 5 to 5.0 mg· L^-1 , linear relationships between the magnitude of increase in CL intensity and concentration of LNGT were obtained. Based on these facts, a new FI-CL method for determination of LNGT in its tablets was proposed with a detection limit （S/N= 3） of 6.4 μg·L^- 1. Precision of the method was tested at the concentration level of 0. 1 mg · L6-1 of LNGT with 11 determinations, giving value of RSD of 4. 3%.

关 键 词：流动注射 化学发光法 高锰酸钾 亚硫酸钠 左炔诺孕酮 

分 类 号：O657.3[理学—分析化学]