纯红系白血病（M6b）一例报告——附文献复习  

Clinical features of pure erythroid leukemia -- case report and review of literature

作　　者：张彦明[1] 吴德沛[2] 孙雨梅[1] 陆沭华[1] 朱明清 

机构地区：[1]徐州医学院附属淮安医院淮安市第二人民医院血液科,223002 [2]苏州大学附属第一医院血液科 [3]江苏省血液研究所

出　　处：《中华血液学杂志》2008年第5期293-295,共3页Chinese Journal of Hematology

摘　　要：目的提高对纯红系白血病（M6b）生物学本质的认识。方法报告1例纯红系白血病患者的临床和实验室检查特征、治疗经过、预后并结合文献复习讨论。结果患者骨髓原始红细胞占0．904，免疫表型：CD71^＋细胞占99．5％、血型糖蛋白A（GPA）^＋细胞占67．4％，无干祖细胞、髓系、淋系、巨核系抗原表达，予以HAG（高三尖杉酯碱＋阿糖胞苷＋G-CSF）方案化疗无效，病情持续进展，多发性髓外浸润，很快死于多器官功能衰竭。结论纯红系白血病恶性程度高，对常规化疗方案治疗无效，预后极差。Objective To report a case of pure erythroid leukemia. Methods The clinical features, treatment and prognosis of a rare case of pure erythroid leukemia were reported, and the related literature was reviewed. Results The pure erythroid leukemia patient was diagnosed by 90.4% pronormoblasts in bone marrow, 99.5% for erythroid antigen CD71,67.4% for glycophorin A were detected, while no differentiation antigen of myeloid, lymphoid and megakaryocyte lineages were observed. HAG （ homoharringtonine ＋ Cytarabine and G-CSF） regimen were administered with no effect. The patient developed multiple organ failure and died soon. Conclusion Pure erythroid leukemia has a fulminant clinical course with poor response to chemotherapy and worse prognosis.

关 键 词：白血病 红细胞 血型糖蛋白A 多器官功能衰竭 

分 类 号：R686[医药卫生—骨科学]