伊托必利在复合外伤术后患者恢复胃肠功能中的作用  

Role of itopride hydrochloride in gastrointestinal function recovery of postoperative patients with compound trauma

作　　者：王斯闻[1] 印春铭[1] 邹延红[1] 刘丹[1] 李春香[1] 张恒[1] 郭俊[2] 桑海泉[1] 

机构地区：[1]中国医科大学附属第四医院ICU,辽宁省沈阳市110032 [2]沈阳市第一人民医院(沈东医院)内科,辽宁省沈阳市110032

出　　处：《世界华人消化杂志》2008年第13期1465-1467,共3页World Chinese Journal of Digestology

摘　　要：目的:探讨胃肠动力药伊托必利在复合外伤的患者术后恢复胃肠动力的效果.方法:复合外伤术后入ICU患者44例,随机分为伊托必利治疗组(n=24),多潘立酮对照组(n=20).治疗组每次po(鼻饲)盐酸伊托必利片50mg,3次/d;对照组每次po(鼻饲)多潘立酮片10mg,3次/d.两组均连续用药1wk,观察有效率和不良反应发生率.各指标之间相关因素的差异性比较采用χ2检验.结果:伊托必利可使复合外伤患者术后消化道功能明显改善,其疗效与多潘立酮相似(χ2=0.761,P>0.05);伊托必利可显著改善胃排空功能,与多潘立酮相比差异有显著性(χ2=6.704,P<0.05).药物不良反应发生率分别为17%和10%,二者比较差异无显著性(P>0.05).结论:伊托必利能快速恢复复合外伤术后患者的胃肠动力并且安全.AIM：To observe the efficacy of itopride hydrochloride in recovering the gastrointestinal function of postoperative patients with compound trauma. METHODS：Forty-four postoperative patients with compound trauma were randomly divided into groups A（n=24）and B（n=20）,treated with IHC（50 mg,3 times per day）and domperidone（10 mg,3 times per day）for 1 wk.The efficacy and adverse reaction were observed and the data were processed by chi-square test. RESULTS：Symptoms of the digestive systemwere improved in both groups,and there was no significant difference between them（χ^2=0.761, P〉0.05）.Compared with group B,the gastric emptying rate of patients in group A significant- ly increased（χ^2=6.704,P〈0.05）.The incidence rate of adverse reaction was 17%in group A and 10%in group B,and there was also no marked difference between the two groups（P〉0.05）. CONCLUSION：Itopride hydrochloride can ef- fectively and safely improve the gastrointestinal function in postoperative patients with com pound trauma.

关 键 词：盐酸伊托必利 多潘立酮 复合外伤 胃肠动力障碍 

分 类 号：R641[医药卫生—外科学]