注射挥发性麻醉药对动物的效应  

Effects of Volatile Anesthetics Injection in Animals.

作　　者：戴体俊[1] 叶妙[1] 傅英[1] 

机构地区：[1]徐州医学院麻醉药理学教研室

出　　处：《临床麻醉学杂志》1997年第5期262-263,共2页Journal of Clinical Anesthesiology

摘　　要：研究了注射挥发性麻醉药对动物的效应。在小鼠，乙醚的催眠ＥＤ５０是５．３５（ｓｃ）和１．６２（ｉｐ）ｍｌ／ｋｇ；ＬＤ５０是１３．７（ｓｃ）和２．３２（ｉｐ）ｍｌ／ｋｇ。甲氧氟烷的ＥＤ５０为０．７５（ｉｐ）和４．１２（ｉｍ）ｍｌ／ｋｇ；ＬＤ５０为１．２３（ｉｐ）和５．８１（ｉｍ）ｍｌ／ｋｇ。ｉｐ氟烷的ＥＤ５０和ＬＤ５０分别是１．２０和１．９４ｍｌ／ｋｇ，ｉｐ安氟醚的ＥＤ５０和ＬＤ５０分别是３．０１和７．５０ｍｌ／ｋｇ。在兔，甲氧氟烷、氟烷和安氟醚静注的催眠ＥＤ５０分别为０．０３０、０．０３６和０．０６４ｍｌ／ｋｇ。这些结果提示，动物注射挥发性麻醉药肯定能引起麻醉，但给人注射挥发性麻醉药是否可行，尚需进一步探讨。Effects of volatile anasthetics injection were studied in animals. The hypnotic ED 50 of diethyl ether(DE) was 5 35ml/kg(sc) and 1 62ml/kg(ip). The LD 50 of DE was 13 7ml/kg(sc) and 2 32ml/kg(ip) in mice. The ED 50 of methoxyflurane (M) was 0 75ml/kg(ip) and 4 12ml/kg(im). The LD 50 of M was 1 23ml/kg(ip) and 5 81ml/kg(im) in mice. The ED 50 of fluothane (F) was 1 20ml/kg(ip). The LD 50 of F was 1 94ml/kg(ip) in mice. The ED 50 of enflurane (E) was 3 01ml/kg(ip). The LD 50 of E was 7 50ml/kg in mice. The hypnotic ED 50 of F, M and E was 0 030,0 036 and 0 064ml/kg in rabbits respectively. These results suggest that whether volatile anesthetics injection can produce anesthesia in man needs to be studied further.

关 键 词：挥发性麻醉药 乙醚 氟烷 安氟醚 药理学 

分 类 号：R971.2[医药卫生—药品]