大肠埃希菌对氟喹诺酮类和阿米卡星的耐药性分析  

Resistance to fluoroquinolones and amikacin in escherichia coil isolates

作　　者：安新[1] 熊自忠[1] 曹鸿霞[1] 

机构地区：[1]安徽医科大学第一附属医院感染病科,安徽省合肥230022

出　　处：《中国基层医药》2008年第4期540-541,共2页Chinese Journal of Primary Medicine and Pharmacy

基　　金：安徽省自然科学基金资助项目（050430804）

摘　　要：目的了解大肠埃希菌对氟喹诺酮类和阿米卡星的耐药性。方法CLSI表型确证试验（纸片增强法）检测产超广谱β-内酰胺酶（ESBLs）菌株，脂稀释法进行药敏试验。结果361株大肠埃希菌中，产ESBLs菌株的检出率为33．8％（122／361）。产ESBLs菌株对环丙沙星、左氧氟沙星、阿米卡星的耐药率分别为93．4％、90．9％、13．1％；非产ESBLs菌株对环丙沙星、左氧氟沙星、阿米卡星的耐药率分别为69．5％、68．6％、19．7％。结论大肠埃希菌对阿米卡星较为敏感；对氟喹诺酮类耐药显著，且产ESBLs菌株的耐药率高于非产ESBLs菌株。Objective To investigate the resistance to fluoroquinolones and amikacin in escherichia coli isolates. Methods ESBLs-producers were detected by CLSI phenotypic confirmatory test and susceptibilities were tested by agar dilution method. Results 33. 8% of 361 isolates were ESBLs-producers. The resistant rate of ciprofloxacin,levofloxacin, amikaxin was 93. 4 %, 90.9 % , 13. 1% in ESBLs-producers, and that was 69.5 % , 68.6 %, 19.7 % in non-ESBLs-producers,respectively. Conclusion Amikaxin is active against most escherichia coli isolates ; those isolates are highly resistant to fluoroquinolones, especially,in ESBLs-producers.

关 键 词：埃希氏菌属 环丙沙星 氧氟沙星 阿米卡星 抗药性 细菌 

分 类 号：R446[医药卫生—诊断学]