早期应用益生菌防治早产儿胃食管反流的临床研究  

Effect of probiotics for Gastroesophageal reflux in premature infants

作　　者：向建文[1] 杨琳琳[1] 杨杰[1] 

机构地区：[1]广州医学院附属广东省妇儿医院广东省妇幼保健院新生儿科,510010

出　　处：《中国优生与遗传杂志》2008年第5期83-84,共2页Chinese Journal of Birth Health & Heredity

基　　金：广东省科技计划项目资助(项目编号:2007B031500009)

摘　　要：目的评估早产儿早期应用益生菌后对早产儿胃食管反流的预防作用。方法将可以进行喂养的80例早产儿随机分成两组,40例予常规喂养基础上加上益生菌喂养作益生菌组,另40例只予常规喂养的作对照组,喂养2周后监测两组早产儿的胃食管pH值变化。结果益生菌组早产儿反流发生的次数、反流超过5min的次数、最长反流持续时间、食管pH<4总时间、反流指数分别是25.7±5.2、4.5±0.7、10.6±1.1、32.6±8.4、5.3±0.6;均低于对照组,差异均有非常显著意义(P<0.05)。结论早期应用益生菌能改善早产儿的胃肠动力,减少胃食管反流的发生和减轻反流程度。Objective：To investigate the effects of probiotics for Gastroesophageal reflux in premature infants.Methods：80 premature infants were devidied into 2 groups,40 cases were treated with probiotics,40 cases of control group were treated with usually way,The distal 24 h esophageal pH monitoring was performed in all premature infants.Results：The 24h esophageal pH monitoring revealed that the variables of acid reflux in probiotics group were significantly lower than those controls.the number of reflux episodes was 28.7±5.2,the number of reflux over 5 rain was 4.7±0.7,the longest time of reflux was 11.6±1.1min,the total time of pH〈4 was2007-12-07 32.6±8.4.8min,the reflux index was 5.5±0.6.Conclusion：probiotics can significantly decrease Gastroesophageal reflux in premature infants.

关 键 词：早产儿 益生菌 24H食管PH监测 胃食管反流 

分 类 号：R722.6[医药卫生—儿科]