生长素对冠状动脉粥样硬化发病及稳定性的作用研究  

Plasma Ghrelin Level in Patients With Coronary Atherosclerosis

作　　者：韩萍[1] 丁文惠[1] 褚松筠[1] 史力斌[1] 韩晓宁[1] 庞永正[1] 唐朝枢[1] 

机构地区：[1]北京大学第一医院心内科,北京市100034

出　　处：《中国循环杂志》2008年第2期90-93,共4页Chinese Circulation Journal

摘　　要：目的:探讨生长素在冠心病患者血浆中的变化以及与冠状动脉粥样硬化发病及稳定性的关系。方法:酶联免疫法测定123例冠心病患者(冠心病组,稳定性心绞痛患者50例、非ST段抬高急性冠脉综合征患者73例)和22例正常对照组的空腹血浆生长素水平。结果:冠心病组患者血浆生长素水平显著低于正常对照组[(2.027±0.935)pg/mL vs(4.756±1.383)pg/mL,P<0.01],稳定性心绞痛和非ST段抬高急性冠脉综合征两部分患者血浆生长素水平无显著性差异[(1.907±0.908)pg/mL vs(2.109±0.951)pg/mL P>0.05];多因素分析显示低血浆生长素水平是冠心病发病的独立危险因素;在非ST段抬高急性冠脉综合征患者中血浆生长素水平与肌钙蛋白I(cTnI)、高敏C反映蛋白(hsCRP)无相关性;在非ST段抬高急性冠脉综合征患者中cTnI≥0.1 ng/dl的患者血浆生长素水平与代表冠状动脉病变程度的Gensini评分呈负相关(r= -0.263,P<0.05)。结论:冠心病患者血浆生长素水平显著降低,低水平的血浆生长素水平可能对冠心病的发病有一定的影响,并且与冠状动脉病变程度有关,但与冠状动脉病变的稳定性不相关。Objective：To evaluate the alterations of plasma ghrelin concentration in patients with coronary artery disease and to investigate its effect on the development and stability of coronary atherosclerosis. Methods：Fasting plasma ghrelin concentration was measured in 123 patients with coronary artery disease（50 with stable angina pectoris, 54 with unstable angina pectoris and 19 with non-ST-elevation myocardial infarction） and 22 normal control subjects with enzyme immunoassay （EIA）. Results ： Plasma ghrelin concentration in patients with coronary artery disease was significantly lower than that in healthy con- trois （2. 027 ±0. 935 pg/ml vs 4. 756 ± 1. 383 pg/ml,P 〈0.01 ）. There was no significant difference in plasma ghrelin concentration in patients with stable angina pectoris and non-ST-elevation acute coronary syndrome （ 1. 907 ± 0. 908 pg/ml vs 2. 109 ± 0. 951 pg/ml, P 〉0.05 ）. there was no correlation was found between plasma ghrelin concentration versus cTnI and hs-CRP in non-ST-elevation acute coronary syndrome. Plasma ghrelin concentration was negatively correlated with Gensini score in patients with non-ST-elevation acute coronary syndrome and plasma cTnI≥0. 1 ng/dl （r = -0. 263, P 〈0. 05）. Conclusion：Low plasma ghrelin concentration is an independent risk factor of coronary heart disease, but it is not correlated with the stability of coronary athrosclerosis.

关 键 词：生长素 冠状动脉粥样硬化 发病 稳定性 

分 类 号：R541[医药卫生—心血管疾病]