羟磷灰石/聚乙丙交酯生物复合材料的研究进展  

Research advancement of hydroxyapatite/poly-lactic-co-glycolic acid biocomposite material

作　　者：赵君[1] 蒋欣泉[1] 张志愿[1] 

机构地区：[1]上海交通大学医学院附属第九人民医院口腔颌面外科,上海200011

出　　处：《国际口腔医学杂志》2008年第2期207-209,共3页International Journal of Stomatology

基　　金：国家自然科学基金资助项目(30400502);上海市科委基金资助项目(04DZ05601;05DJ14006;055407034;05QMX1426)

摘　　要：羟磷灰石/聚乙丙交酯(HA/PLGA)复合材料是无机/有机复合材料的典型代表。材料制备工艺的改进使得材料更有利于细胞的黏附,具有更好的生物相容性;纳米技术的应用,增加了材料的生物活性,同时也提高了材料的骨整合性与骨传导性;仿生矿化的研究发现不同磷灰石晶体大小和形态的微环境会影响细胞的伸展、增殖以及其向成骨细胞的分化;表面吸附和共沉淀作用可以将生长因子吸附到材料表面形成生长因子的缓释载体,而共沉淀作用相比表面吸附的方法具有更多的优点。Hydroxyapatite/poly-lactic-co-glycolic acid （HAfPLGA） biocomposite material is one typical representative of inorganic/organic composite materials. With the improvement of the preparation of the material, it＇s easier to cell adhere and the material has better biocompatibility. The application of nanotechnique had improved the bioactivity of the material as well as the osteointegration and the osteoconduction. The study of biomimetic mineralization suggests that different size and shape of apatite microenvironment affects the cell spreading, proliferation and the osteogenic differentiation. By surface adsorption and coprecipitation, the bioactive growth factors could absorb to the surface of the material, so a desired delivery system of biological factors for bone tissue engineering could therefore be designed. But the method of coprecipitation has more advantage compared with surface adsorption.

关 键 词：羟磷灰石 聚乙丙交酯 骨组织工程 支架材料 

分 类 号：R318.08[医药卫生—生物医学工程]