急性冠状动脉综合征患者血清BNP水平与hs-CRP、cTNI水平的相关性研究  

Research on the correlation of serum BNP with hs-CRP and cTNI in patients with acute coronary artery syndrome

作　　者：宋军[1] 任绪功[1] 王平[1] 宋执敬[1] 李勇[1] 荆媛[1] 

机构地区：[1]山东德州市人民医院,山东德州253014

出　　处：《国际内科学杂志》2008年第5期255-257,共3页International Journal of Internal Medicine

摘　　要：目的探讨急性冠状动脉综合征(ACS)患者血清脑利钠肽(BNP)与高敏C反-应蛋白(hs-CRP)、心肌肌钙蛋白I(cTNI)指标的相关性及其在ACS患者危险分层中可能的临床意义。方法ACS患者41例包括急性心肌梗死患者21例和不稳定型心绞痛患者20例;稳定型心绞痛患者29例和与之年龄、性别等相匹配的30例对照者进入本研究。酶联免疫吸附法测定血清BNP水平,免疫比浊法测定hs-CRP水平,化学发光法测定cTNI水平。结果急性心肌梗死组和不稳定型心绞痛组患者的血清BNP水平均明显高于稳定型心绞痛和对照组患者,差异均具有统计学意义(P<0.01和P<0.05);在ACS组中,BNP与cTNI和hs-CRP具有相关性(r分别为0.67和0.91,P<0.05)。结论①血清BNP水平在ACS患者中明显升高,可作为辅助诊断指标之一。②ACS患者血清BNP水平升高程度与同期测定的血清hs-CRP、cTNI水平呈显著正相关。Objective To study the correlation of serum brain natriuretie peptide（BNP） with high-sensitivity C-reactive protein（hs-CRP） and cardiac troponin I （cTNI） in patients with acute coronary syndrome（ACS）, thus to investigate the clinical meaning of BNP as a new biochemistry marker in risk stratification of ACS patients. Methods Patients with ACS including 21 cases of acute myocardial infarction （AMI） patients and 20 cases of unstable angina pectoris （UAP） patients; 29 cases of stable angina pectoris （SAP） and 30 patients without cardiovascular diseases（ control group） were enrolled. The serum level of BNP, hs-CRP and cTNI were tested, The data was analyzed with SPSSll. 5 statistical software. Results The serum level of BNP in AMI and UAP patients was significantly higher than that in SAP and control patients（P 〈 0. 05 ）. The serum level of BNP was positive correlated with hs-CRP and cTNI （r was 0. 91 and 0. 67 respectively, P 〈 0. 05 ） in ACS group. Conclusions The serum level of BNP is significantly higher in ACS patients. It may be another bio- chemistry marker to predict the prognosis and risk stratification of ACS patients.

关 键 词：急性冠状动脉综合征 脑利钠肽 高敏C反应蛋白 心肌肌钙蛋白I 

分 类 号：R541.4[医药卫生—心血管疾病]