健康青少年视觉注意作业的功能性磁共振成像初步研究  

Primary study on brain activity during visual attentional task in healthy adolescent using functional magnetic resonance imaging

作　　者：吴丽慧[1] 赵钱雷[2] 尹玲玲[2] 王美豪[3] 李建策[3] 叶笃筠[1] 

机构地区：[1]华中科技大学同济医学院 [2]温州医学院附属育英儿童医院儿童保健科 [3]温州医学院附属一院放射科

出　　处：《中国康复医学杂志》2008年第5期388-390,415,共4页Chinese Journal of Rehabilitation Medicine

基　　金：浙江省自然科学基金资助项目(M303002);浙江省科技厅国际合作面上项目(2004C34008)

摘　　要：目的:应用功能性磁共振成像(fMRI)探讨视觉注意作业时健康青少年脑功能定位。方法:使用美国GE1.5 TSigna Horizon LX超导型磁共振仪,对19名健康青少年进行视觉注意作业的fMRI检查,采用梯度回波-平面回波成像序列采集数据,经工作站处理后获功能图像。同时进行氢谱分析。结果:健康青少年视觉注意作业测验激活脑区的范围较广泛,不同脑区的激活计数不同,9岁—12岁和13岁—15岁两个年龄段比较,结果无显著性差异(P>0.05)。本研究健康青少年双侧苍白球1HMRS结果(峰下面积比值):左侧,NAA/Cr3.24±1.27、cho/Cr0.71±0.15、ml/Cr0.66±0.17、a-Glx/Cr0.84±0.18;右侧,NAA/Cr3.17±1.12、cho/Cr0.66±0.19、ml/Cr0.60±0.16、a-Glx/Cr0.71±0.28。经Fisher精确检验法,健康青少年双侧额上回、双侧额中回和左侧额下回的激活脑区计数与理想激活脑区计数的差异均无显著性,其余脑区激活计数的差异均有显著性。结论:本组健康青少年脑区激活计数及氢谱分析可供临床参考。视觉注意作业主要涉及记忆信息的提取速度和注意能量,双侧额叶可能参与其过程。Objective： To investigate the characteristics of brain activity during visual attentional task using functional magnetic resonance imaging （fMRI）. Method： The data of 19 healthy adolescent were collected when they performed the visual attentional task, using brain fMRI and proton magnetic resonance spectroscopy. The data of activation and rest images were reconstructed with an offline workstation and the activation map was obtained. Result：The activated brain areas were comprehensive during the visual task of attention and the number of activated areas was diversified in different brain areas. The comparison between 9-12 years-old and 13--15 years-old showed no significant difference, such brain areas as frontal lobe, temporal lobe were significantly activated. The data on ^1H MRS in bilateral globus pallidus （GP） of healthy adolescent in this study was as follows： In the left GP, NAA/Cr was 3.24±1.27, cho/Cr was 0.71±0.15, ml/Cr was 0.66±0.17, a-Glx/Cr was 0.84±0.18 while in the right GP, NAA/Cr was 3.17±1.12, cho/Cr was 0.66±0.19, ml/Cr was 0.60±0.16, a-Glx/Cr was 0.71±0.28. No significant difference was found in bilateral superior frontal gyms, bilateral middle frontal gyms, and left inferior frontal gyms in healthy adolescent and significant differences were found in other brain areas.Conclusion：The results provide the possible reference range of activated areas＇ number and the ＇H MRS of brain areas for clinical work. It indicates that visual task of attention mainly might be related to the retrieval of memory and attention source, and the bilateral frontal lobe might be involved in the visual task of attention.

关 键 词：健康青少年 功能性磁共振成像 视觉注意作业 额叶 

分 类 号：R445.2[医药卫生—影像医学与核医学] R338.3[医药卫生—诊断学]