乙肝病毒前S_2抗原与HBV血清标志物和HBV DNA相关性分析  

Study of correlations among HBV M and HBV DNA and Pre S_2 in HBV infection

作　　者：沈国平 姚娟 毕丹 

机构地区：[1]浙江省湖州市妇幼保健院检验科,浙江湖州313000

出　　处：《中国卫生检验杂志》2008年第3期483-484,500,共3页Chinese Journal of Health Laboratory Technology

摘　　要：目的:通过对乙肝病毒前S2抗原(Pre S2)与乙肝病毒(HBV)血清标志物及HBV DNA检测的对比分析,进而对乙肝病毒前S2抗原临床应用价值进行探讨。方法:对226例HBsAg阳性标本采用酶联免疫吸附试验(ELISA)检测HBV血清标志物和Pre S2及荧光定量聚合酶链反应(FQ-PCR)检测HBV DNA。结果:226例HBsAg阳性标本中,Pre S2与HBeAg、HBV DNA的总符合率分别为62.8%和74.3%,与HBeAg、HBV DNA之间均关联显著;Pre S2与HBeAg之间差异有统计学意义,与HBV DNA之间差异无统计学意义;Pre S2的检出率高于HBeAg。结论:Pre S2的检测可以较好的反映HBV存在和复制情况,Pre S2作为辅助或补充指标联合HBV血清标志物与HBV DNA同步动态检测,具有重要的临床应用价值。Objective：The HBV antigen S2 clinical value was explored by study of correlation among HBV M and HBV DNA and Pre S2 with HBV infection, nethods：A total of 226 positive specimens of HBsAg with the serum enzyme - linked immunosorbent assay （ELISA） were detected serum Pre S2 with ELISA and HBV DNA with the fluorescence quantitative polymerase chain reaction （ FQ - PCR）. Results：In 226 HBsAg positive specimens, the general rate of Pre S2 coincidence with HBeAg was 62. 8% and HBV DNA was 74. 3% respectively. The correlations among Pre S2 and HbeAg and HBV DNA were significance. The correlation was non - significance between HBV DNA and Pre - S2. The positive rate of Pre S2 was higher than the HBeAg＇s. Conclusion：The Pre S2 maybe to be an important assistance or a supplement factor of HBV infection＇s diagnosis and treatment, because it can reflect the HBV existence and the duplication situation with HBV infection better.

关 键 词：前S2抗原 乙型肝炎病毒标志物 乙型肝炎病毒DNA 

分 类 号：R512.62[医药卫生—内科学]