贵州省玉屏、镇远、岑巩县农村人群乙型肝炎病毒感染调查  

Investigation of hepatitis B infection of rural population in Yuping,Zhenyuan and Cengong in Guizhou Province

作　　者：周峻[1] 田兴国[2] 吉光辉[3] 高岚[4] 唐光鹏[5] 邓军[6] 吴国刚 高前荣 

机构地区：[1]贵州省黔东南州疾病预防控制中心,贵州凯里556000 [2]贵州省六盘水市疾病预防控制中心,贵州六盘水553001 [3]贵州省遵义市疾病预防控制中心,贵州遵义563002 [4]贵阳市疾病预防控制中心,贵阳550003 [5]贵州省疾病预防控制中心,贵阳550003 [6]贵州省黔南州疾病预防控制中心,贵州福泉550000 [7]贵州省黔西南州疾病预防控制中心,贵州兴义562400 [8]贵州省铜仁地区疾病预防控制中心,贵州铜仁554300

出　　处：《中国卫生检验杂志》2008年第3期520-523,共4页Chinese Journal of Health Laboratory Technology

摘　　要：目的：为了解玉屏、镇远、岑巩的洞坪、沙水坪、洪家湾、异溪、响水等5个村人群乙肝病毒感染状况。方法：每村随机抽取各年龄组人群150人，用酶联吸附试验（ELISA）法对血清进行检测。结果：HBsAg、抗-HBs、HBeAg、抗-HBe、抗-HBc阳性率和HBV感染率分别为6.49%、31.35%、3.92%、2.57%、18.11%和42.16%。HBV感染模式以模式13（5项血清学标志物均阴性）、模式8（仅抗-HBs阳性）和模式12（仅抗-HBc阳性）最多（占检测总数84.87%）。HBsAg、抗-HBs、HBeAg、抗-HBc阳性率和HBV感染率随着年龄的增大逐渐增高，HBsAg和HBeAg阳性率在20-29岁最高（分别为10.94%和9.38%），以后HBsAg阳性率逐渐下降，而HBeAg阳性率下降后，在50-59岁又有一个小高峰（7.14%），抗-HBs、抗-HBc阳性率和HBV感染率在30-39岁形成成人峰（分别为50.57%、31.03%和61.67%），以后维持在较平稳的水平。结论：为了阻断HBV传播，首先，对易感人群尤其是新生儿和20岁以下青少年进行乙肝疫苗预防接种；其二，强化对卫生医疗机构和饮食等服务行业的卫生监督执法力度；其三，加强健康教育。Objective：To know the current infectious state of the hepatitis B in Dongping, Shashuiping, Yixi and Xiangshui villages of Yuping,Zhenyuan and Cengong counties. Methods：Fetching the vein blood of 150 people in each village by cluster random sampling method and the samples were tested by enzyme linked immunosorbent assay （ELISA）. Results：The positive rate of HBsAg, anti - HBs, HBeAg, anti - HBe, anti - HBc and HBV prevelant was 6. 49%, 31.35%, 3. 92%, 2. 57%, 18. 11% and 42. 16%. The major models of HBV infection were model 13 （all of HBsAg, anti - HBs, HBeAg, anti - HBe, anti - HBc were negative）, model 8 （only anti - HBs was positive） and model 12 （ only anti - HBc was positive） （84. 87% of tested samples）. The positive rates of HBsAg, anti - HBs, HBeAg, anti - HBc and HBV prevelant were increasing along with ages. The highest positive rate of HBsAg and HBeAg was 20 - 29 years old （ 10. 94% ,9. 38% ）, and then the positive rate of HBsAg made a slow descent and the positive rate of HBeAg had a small peak time in 50 - 59 years old（7. 14% ）after decrease. The positive rate of anti - HBs, anti - HBc and HBV prevelant attached their peak time in 30 - 39 years old（50. 57% ,31.03% ,61.67% ）, and then the positive rate of anti - HBs, anti - HBc and HBV prevelant maintain in the stable level. Conclusion. In order to control HIV transmission, HB vaccine should be inoculated in the suspected people, especially newborns and those of less than 20 years old. Meanwhile, we must strengthen the public health supervison to hospitals, clincs, food industry and public places and grasping the health education.

关 键 词：乙型肝炎病毒 血清标志物 检测 

分 类 号：R512.62[医药卫生—内科学]