血管紧张素原M235T基因多态性及体重指数与原发性高血压的关系  

The relationship between M235T allete polymorphism of angiotensinogen,BMI and essential hypertension

作　　者：周晓红[1] 路方红[1] 金世宽[1] 刘振东[1] 孙尚文[1] 赵颖馨[1] 王舒健[1] 杨建民[1] 

机构地区：[1]山东省医学科学院心血管防治研究中心,山东济南250062

出　　处：《中国老年学杂志》2008年第9期875-877,共3页Chinese Journal of Gerontology

基　　金：山东省自然科学基金资助项目(Y2005c25)

摘　　要：目的探讨血管紧张素原(ATG)基因多态性及体重指数与高血压的关系。方法采用聚合酶链反应结合限制性内切酶消化,对72例原发性高血压患者和78例血压正常者血管紧张素原的M235T基因多态性进行检测。结果高血压组收缩压、体重指数和血管紧张素原水平均高于正常对照组(P<0.05);高血压组与对照组的MM、MT和TT基因型频率分别为0.347、0.319、0.333,0.564、0.244、0.192,差异明显(P<0.05),TT基因型患高血压的相对危险最高。调整多种混杂因素后,Logistic回归分析示T等位基因和体重指数均不同程度的增加了高血压患病的危险性,同时二者存在着协同作用。结论T等位基因、体重指数是预测高血压危险性的有效指标,且二者存在协同效应。控制体重可以有效地防治高血压。Objective To study the association of angiotensinogen gene polymorphism and body mass index （BMI） in essential hypetension （EH）. Methods Polymerase chain reaction with restrict enzyme digestion was used to detect the target gene polymorphism in 78 normotension controls and 72 EH patients. Results There was a significant difference between normotension controls and EH on patients in systolic pressure, BMI and angiotensinogen （P 〈 0. 05） ; The genotypic frequency met the Hardy-Weinberg balance, there was a significant difference in the genotypic frequency of MM, MT and Tr between normotension controls （0. 564,0. 244,0. 192） and EH patients （0. 347, 0. 319,0. 333 ） （ P 〈 0.05 ）, with Tr genotype having the highest prevalence rate of hypetension. Logistic regression showed that T allele and BMI all increased the prevalence risk of hypetension, meanwhile the T allele and BMI had certain synergistic action for prevalence rate of hypetension. Conclusions T allele and BMI are effective to predict hypetension, and keeping weight could prevent hypetension.

关 键 词：血管紧张素原 基因多态性 体重指数 原发性高血压 

分 类 号：R544[医药卫生—心血管疾病]