黑紫橐吾化学成分的分离与鉴定  

Separatian and Identification of Constituents from Ligularia atroviolacea

作　　者：施树云[1] 赵昱[2] 张宇平[1] 黄可龙[1] 刘素琴[1] 

机构地区：[1]中南大学化学化工学院,长沙410083 [2]浙江大学药学院中药与天然药物研究室,杭州310058

出　　处：《高等学校化学学报》2008年第5期941-943,共3页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:20376085)资助

摘　　要：利用各种色谱技术对黑紫橐吾的乙酸乙酯萃取部位进行分离纯化，并且根据一维和二维波谱数据进行结构鉴定．共分离得到4个呋喃雅槛蓝型倍半萜：1α-氯-6β-异丁酰基-9-酮-10β-羟基-呋喃雅槛蓝烷（1），1α-羟基-6β-异丁酰基-9-酮-10β-氢-呋喃雅槛蓝烷（2），1α-羟基-6β-异丁酰基-9-酮-10α-氢-呋喃雅槛蓝烷（3）和1α，10β-二羟基-6β-当归酰基-9-酮-呋喃雅槛蓝烷（4）．其中化合物1为新化合物，并且通过X射线单晶衍射确定了绝对构型；化合物2～4为首次从该植物中分离得到．A new and three known furanoeremophilanes were separated from Ligularia atroviolacea via chemical investigation, which were identified as 1α-chloro-6β-isobutyroxy-9-oxo-10β-hydroxy-furanoeremophilane （1）, 1α-hydroxy-6β-isobutyroxy-9-oxo-10β-H-furanoeremophilane （2）, 1α-hydroxy-6β-isobutyroxy-9-oxo- 10α-H-furanoeremophilane （ 3 ）, 1α, 10β-dihydroxy-6β-angeloyloxy-9-oxo-furanoeremophilane （ 4 ）. Their structures were established by spectroscopic methods including 2D-NMR. The absolute structure of compound 1 was determined by X-ray diffraction analysis.

关 键 词：黑紫橐吾 分离纯化 结构鉴定 呋喃雅槛蓝型倍半萜 X射线衍射 

分 类 号：O629[理学—有机化学]