中药制剂及给药系统的物质组释放／溶出动力学原理  

Principles of chemomic release/dissolution kinetics for Chinese materia medica in conventional dosage forms or drug delivery systems

作　　者：陈立兵[1] 张继稳[2] 顾景凯[3] 葛卫红[1] 

机构地区：[1]浙江中医药大学药学院,浙江杭州310053 [2]中国科学院上海药物研究所药物释放系统研究中心,上海201203 [3]吉林大学药物代谢研究中心,吉林长春130021

出　　处：《中草药》2008年第5期641-644,共4页Chinese Traditional and Herbal Drugs

基　　金：国家高技术研究发展计划(“863”计划)资助项目(2006AA02Z336);国家科技支撑计划项目(2006BAI098B08-08);中国科学院上海药物研究所新药基础研究项目资助(07G603F015)

摘　　要：介绍中药物质组释放/溶出动力学相关概念、定理和原理,以及该理论的评价原理、评价方法和基本评价过程。形象化的展示有利于理解中药物质组、物质组浓度和物质组释放度等概念,更好地将该理论推广和应用到中药给药系统设计、评价中,并在药物动力学水平赋予传统剂型新的内涵。该理论将为传统中药制剂的现代化及其评价、中药给药系统的设计和评价提供新的思路和方法学依据。The concepts, theorems, and principles of the chemomic release/dissolution kinetics for Chinese materia medica （CMM） were graphically elucidated by the introduction of the research background, evaluation principles and methods, and the primary evaluation process of the new method. A vivid presentation should be able to facilitate the comprehension of the terms and concepts of the chemome of CMM, the chemomic concentration, chemomic release/dissolution profiles, etc. , to further promote the application of the new theory in design and evaluation of CMM in drug delivery systems, and to renew the conventional dosage forms of CMM in pharmacokinetic level. The theory could provide a thinking and methodological basis for the modernization and evaluation of CMM dosage forms, which could be put into an advanced delivery system.

关 键 词：中药 物质组 释药/溶出动力学 

分 类 号：R283.3[医药卫生—中药学]