正常年轻人嗅觉事件相关电位的特点  

Characteristics of olfactory event-related potentials in young adults with normal smell

作　　者：刘剑锋[1] 倪道凤[1] 张秋航[2] 

机构地区：[1]中国医学科学院中国协和医科大学北京协和医院耳鼻咽喉科,北京100780 [2]卫生部中日友好医院耳鼻咽喉科

出　　处：《临床耳鼻咽喉头颈外科杂志》2008年第8期352-355,共4页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

基　　金：科技部基础性工作和社会公益研究专项(No:2003DIB1J077)

摘　　要：目的:研究正常年轻人嗅觉事件相关电位(OERP)的特点。方法:嗅觉正常的健康年轻志愿者55例,使用OEP-98C型嗅觉诱发电位仪,以醋酸异戊酯(刺激浓度<1 648×10-6)为气味刺激剂行OERP测试。在刺激间隔优化测试时,分别采用间隔5次(15 s)、10次(30 s)、20次(60 s)呼吸的刺激间隔。结果:OERP波形分类:①N1P2型;②P1N1P2型;③P1N1P2P3型;④P1N1P2N2P3型。引出率:正常年轻人OERP的引出率为100%。其中P1引出率为60.4%,P2引出率为100.0%,P3引出率为32.1%。男女引出率差异无统计学意义(P>0.05)。潜伏期:P1、N1、P2、N2、P3潜伏期分别为(233±32)ms、(365±52)ms、(511±90)ms、(625±56)ms、(717±88)ms;男女各波潜伏期差异无统计学意义(P>0.05)。幅值:P1、N1、P2、N2、P3幅值分别为(7.22±5.93)μV、(-6.00±2.56)μV、(16.65±8.19)μV、(6.35±3.55)μV、(13.23±6.93)μV;以上各波男女间幅值差异无统计学意义(P>0.05)。N1P2幅值为(22.58±8.25)μV,男性为(19.53±6.89)μV,女性为(25.24±8.44)μV,女性N1P2幅值大于男性(P<0.05)。随刺激间隔增加,P2和N1P2幅值增加;潜伏期无显著改变。结论:正常年轻人OERP P2的引出率为100%,P1引出率较P3高,性别、刺激间隔是影响N1P2幅值的因素。Objective： To investigate the characteristics of OERPs of young adults. Method： Subjects included 55 young volunteers （male/female 25/30） with normosmia. A complete ENT examination, A subjective olfactometry with T＆T olfactometer were performed in all subjects. OERPs with stimulus isoamyl acetate （〈 1 648 × 10^-6 ）, and air control were obtained in volunteers. Result： OERPs were obtained in both male and female volunteers. P2, the primary component of OERPs, was identified in all volunteers. No significant difference was found in latencies of the components of OERPs between male and female volunteers. N1-P2 interpeak amplitudes were larger in the female subjects than male subjects （P〈0.05）. Conclusion：P2 component of OERPs is identified in all young adults, both gender and interstimulus interval have impact on N1-P2 interpeak amplitudes.

关 键 词：嗅觉事件相关电位 嗅觉 嗅觉测试 

分 类 号：R765[医药卫生—耳鼻咽喉科]