铜绿假单胞菌医院感染的特征及耐药性分析  

Analysis of the distribution and drug-resistance of Pseudomonas aeruginosa in hospital infection

作　　者：李红玉[1] 吴燕峰[1] 邹燕琴[1] 伍锡泉[1] 

机构地区：[1]广州市中山大学附属二院实验室,510120

出　　处：《中国临床实用医学》2008年第5期6-7,共2页China Clinical Practical Medicine

基　　金：广州市科技局重点攻关项目（项目编号：200621-E0141）,广东省自然科学基金项目（项目编号：07001603）

摘　　要：目的了解铜绿假单胞菌引起医院感染的特征及耐药情况，为临床治疗提供理论依据。方法常规方法对本院2006年1月至2007年12月住院患者的各种临床标本进行分离培养，细菌鉴定及药敏试验采用全自动微生物鉴定仪VITEK·TWO进行。结果212株引起医院感染的铜绿假单胞菌主要分布于血症监护科（ICU）占25．5％（54／212），其次神经内科及呼吸科分别为10．8％（23／212）、9．4％（20／212），感染以肺部感染为主，占65．1％（138／212），对临床常用的多种抗菌药物表现交叉耐药，对氨曲南、替卡西林／克拉维酸、头孢哌酮、庆大霉素及妥布霉素的敏感率较低，在60．0％以下；对美诺培南、左氧氟沙星、亚胺培南、环丙沙星的敏感率较高，分别为83．0％、79．2％、76．9％、75．9％。结论引起医院感染的铜绿假单胞菌具有多重耐药性，临床治疗时应根据药敏结果选用抗菌药物。Objective To investigate the distribution and drug-resistance of Pseudomonas aeruginosa （PA） in hospital infection, and to provide the experimental evidence for clinical therapy. Methods The clinical specimens were collected from Jan 2006 to Dec 2007. Identification of the bacteria and Antimicrobial susceptibility test were performed on VITEK · TWO all-automatic microbiology analysis system. Results Lung was the main infected organ of PA. PA showed cross-resistance to multiple antibiotics. Antimicrobial susceptibility test showed that the sensitive rates of PA to Aztreonam, Ticarcillin/Tazobactam, Cefoperazone, Gentamycinand Tobramycin were lower than 60.0%; and the sensitive rates to Meraopenem, Levofloxacin, Imipenem,Ciprofloxacin were 83.0% ,79. 2% ,76. 9% 75.9% respectively. Conclusion PA is multi-resistant to most antimicrobial a- gents. In the treatment of clinical PA infection, drugs should be selected according to the results of antimicrobial susceptibility test.

关 键 词：铜绿假单胞菌 医院感染 耐药性 

分 类 号：R446.5[医药卫生—诊断学]