奉化市中学生麻疹抗体水平监测与初中学生麻疹疫苗加强接种免疫效果分析  

Surveillance of measles antibody levels of middle school students and effect of intensified measles vaccine immunization in junior high school students in Fenghua city

作　　者：王海明[1] 傅叁君 徐永范[1] 袁荣宝[1] 曹云生[1] 竺稽定[1] 陈君斌[1] 周薇[1] 汪妙素[1] 孙静[1] 

机构地区：[1]浙江省奉化市疾病预防控制中心,浙江奉化315500

出　　处：《疾病监测》2008年第4期230-232,共3页Disease Surveillance

摘　　要：目的了解中学生麻疹免疫水平及对初中学生加强接种麻疹疫苗(MV)后的免疫效果。方法选取2005年暴发过麻疹的西坞初中和无麻疹发病的莼湖初中、高中共563名学生进行麻疹IgG抗体监测,并对莼湖初中学生进行MV接种,观察加强接种MV前后和应急接种后的麻疹IgG抗体变化,采集静脉血,用酶联免疫吸附试验法检测麻疹IgG抗体。结果西坞初一、莼湖初中和高中学生麻疹IgG抗体分别为1001、951和813IU/ml,莼湖初中学生免后麻疹几何抗体平均浓度(GMC)为2354IU/ml,为免前的2.48倍,保护性抗体阳性率达97.64%,西坞初二、初三学生在2005年应急接种过MV,GMC为1889IU/ml,保护性抗体阳性率为80.61%。结论初中学生加强接种或应急接种MV较未接种者麻疹抗体升高明显,差异有统计学意义。Objective The study was conducted to identify the measles immunization levels and evaluate the effect of intensified immunization of measles vaccine （MV） among junior high school students. Methods A total of 563 participants including students with measles infection history from Xiwu Junior High School and those without infection history from Chunhu Junior and Senior High School in 2005 received the surveillance of measles IgG antibody levels. The students from Chunhu Junior High school were immunized with measles vaccines. Changes of measles IgG antibody levels were recorded before and after intensified inoculation and emergency inoculation of measles vaccines. The measles IgG antibodies were detected by the ELISA technology from intravenously collected blood samples. Results The measles IgG antibody levels were 1001, 951 and 813 IU/ml among the students from Xiwu Junior High School （grade one）, Chunhu Junior High School and Senior High School, respectively. The geometric mean concentration （GMC） of measles antibodies among Chunhu Junior High School students after inoculation was 2354 IU/ml, 2.48 times before inoculation, the protective antibody positive rate being 97.64%. The students from Xiwu Junior High School （grade two and grade three） that received emergency inoculation of MV in 2005 had the GMC of 1889 IU/ml, the protective antibody positive rate 80.61%. Conclusion Junior high school students with intensified or emergency immunization history of MV present an apparently higher measles antibody level compared with those unvaccinated, and the difference is statistically significant.

关 键 词：初中学生 麻疹疫苗 接种 IGG抗体 

分 类 号：R186[医药卫生—流行病学]