出生体重与胰岛素敏感性关系的双生子研究  

A Twin Study on Relationships Between Birth Weight and Insulin Sensitivity

作　　者：陈天娇[1] 季成叶[1] 

机构地区：[1]北京大学儿童青少年卫生研究所,北京100083

出　　处：《中国学校卫生》2008年第5期434-436,共3页Chinese Journal of School Health

摘　　要：目的研究出生体重与胰岛素敏感性关联的原因,以验证胎源性假说。方法对292对同性别双生子(单卵双生子225对,二卵双生子67对)采用DNA鉴定卵型,问卷询问出生体重,稳态模型胰岛素抵抗指数衡量胰岛素敏感性,分析双生子组内及对内与出生体重和胰岛素敏感性的关系。结果出生体重与个体身高、体重和人体质量指数呈显著正相关,与血糖、胰岛素、稳态模型胰岛素抵抗指数呈显著负相关,男、女生不同。宫内营养不良独立于遗传因素,独立于BMI,对低出生体重和高胰岛素敏感性关联有作用,男生中更为明显。结论个体早期对宫内营养不良的程序化反应导致高胰岛素敏感性,早期宫内营养干预对预防糖尿病有意义。Objective To study the association between birth weight and insulin sensitivity in twins,and to test the fetal origins hypothesis.Methods A total of 292 twin pairs with the same sex were enrolled.DNA microsatellite polymorphism was used to diagnose zygosity of twins.Birth weight was gained by questionnaire and insulin sensitivity was estimated with logarithm transformed and insulin sensitivity within-cohort and within-pair were analyzed separately.Results Positive correlations were found between birthweight and individual stature,weight and body mass index（BMI）,whereas negative correlations were found between birthweight and blood glucose,insulin and insulin resistance index,which were different between boys and girls.Intrauterine malnutrition affected the association between lower birthweight and insulin sensitivity,independent of genetic factors and BMI,especially in boys.Conclusion Insulin sensitivity is due to a programmed response to intrauterine malnutrition partly.Improvements in intrauterine nutrition may prevent diabetes in later life.

关 键 词：出生体重 胰岛素 敏感性与特异性 双生研究 学生 

分 类 号：R179[医药卫生—妇幼卫生保健] R339.35[医药卫生—公共卫生与预防医学]