肺炎支原体肺炎患儿免疫功能变化及结果分析  

Analysis on Alterations of Immune Function in Children with MycoplasmaPneumoniae Pneumonia

作　　者：安黎云[1] 王缚鲲[1] 陈晶[1] 李玮[1] 曾倩[1] 郑运周[1] 王宪灵[1] 

机构地区：[1]白求恩国际和平医院,河北石家庄050082

出　　处：《实用预防医学》2008年第2期544-546,共3页Practical Preventive Medicine

摘　　要：目的观察肺炎支原体肺炎(MPP)患儿外周血淋巴细胞亚群、辅助性T淋巴细胞亚群、B细胞以及免疫球蛋白的含量变化,并探讨其在MPP发病机制中的意义。方法采用流式细胞仪技术检测了43例支原体肺炎患儿和40例正常对照组儿童外周血T淋巴细胞亚群、B淋巴细胞亚群以及Th1、Th2细胞的百分比;并用速率散射比浊法检测血清免疫球蛋白IgG、IgA和IgM的含量。结果MPP患儿外周血CD3+、CD4+T细胞百分率分别为50.03±9.37和30.25±7.11,较对照组65.88±8.83和36.55±6.01显著降低(P<0.05),CD8+T细胞较对照组无显著差别;患儿外周血Th1细胞百分率为14.26±5.78,对照组为21.08±6.83,两者差异极为显著(P<0.01)。Th1/Th2比值较对照组显著降低(P<0.05)。B淋巴细胞和B1细胞较对照组均显著增高(P<0.05)。43例患儿血清免疫球蛋白与正常对照组比较,IgG和IgA均无明显差异,IgM较对照组稍高,其差别有统计学意义(P<0.05)。结论MPP患儿存在机体免疫功能减低,免疫调节功能紊乱,Th1/Th2失衡,且Th1型细胞受抑制,而Th2型细胞介导的免疫反应占相对优势状态。Objective To observe the alterations of peripheral blood lymphocyte subsets, T lymphocyte subsets, B lymphocyte and the immunoglobulin content in children with mycoplasma pneumoniae pneumonia （MPP）, and to explore the possible pathogenesis of MPP. Methods Forty - three pediatric patients with Mycoplasma pneumoniae （Mp） infection during their acute stage and 40 healthy children served as control were involved in this study. The percentages of T lymphocyte subsets and B lymphocyte in the peripheral blood were determined by flow cytometry. The levels of IgG, IgA, and IgM were measured by velocity scatter colorimetry. Results The percentages of CD3 ^＋and CD4 ^＋ T lymphocyte in MPP group were significantly lower than those in control group （P 〈 0.05）. There was no significant difference in the percentages of CD8 ^＋ T lymphocyte, IgG and IgA between the MPP group and control group. There was significant difference in the percentage of Th1 between the two groups （P 〈 0.01 ）. The percentages were higher than those in control group （P〈 0.0.5）. Conclusion of B lymphocyte, B1 lymphocyte and IgM in MPP group There was an unbalanced cell - mediated immunity with a tendency toward Th2 existed in children with MPP infection.

关 键 词：肺炎支原体 T淋巴细胞亚群 TH1细胞 TH2细胞 B1细胞 

分 类 号：R563.1[医药卫生—呼吸系统]