冠心病患者的牙周状况与hs-CRP和HDL-C的相关性研究  

Study on the correlation between the periodontal status of patient with CHD and hs-CRP, HDL-C

作　　者：周骢[1] 聂敏海[1] 李家富[2] 胡佳[1] 

机构地区：[1]四川泸州医学院附属口腔医院,646000 [2]四川泸州医学院附属医院心内科 ,646000

出　　处：《实用口腔医学杂志》2008年第3期428-431,共4页Journal of Practical Stomatology

摘　　要：目的:探讨hs-CRP和HDL-C在慢性牙周炎与冠心病关联中的作用。方法:按照冠心病及慢性牙周炎临床诊断标准,研究对象分为4组:冠心病伴慢性牙周炎组34例、冠心病组28例、慢性牙周炎组30例和对照组31例。记录各组牙周状况,检测血浆中脂类物质及超敏C反应蛋白的水平。结果:冠心病伴(不伴)慢性牙周炎组比对照组牙周状况差。HDL-C在冠心病伴慢性牙周炎组、冠心病组均比对照组低。Hs-CRP在冠心病伴慢性牙周炎组比冠心病组、慢性牙周炎组、对照组高;冠心病组比对照组高;慢性牙周炎组比对照组高。结论:Hs-CRP和HDL可能在慢性牙周炎引发冠心病发生中起了一定的作用,慢性牙周炎和冠心病之间可能有一定的相关性。Objective：To study the relationship between chronic periodontitis （CP） and coronary heart disease （CHD）. Methods： There were 34 cases with CHD and chronic periodontitis, 28 cases with CHD but not chronic periodontitis, 30 cases with only chronic periodontitis, 31 healthy persons. The diagnosis of chronic periodontitis and CHD were based on accepted clinical criteria. The state of periodontal pocket and the clinical symptom were recorded. The level of high sensitive C-reaction protein （hs-CRP）, total cholesterol （TC）, triglyceride（ TG）, low density lipoprotein cholesterol （LDL-C） and high-density lipoprotein cholesterol （HDL-C） were detected. Results： The state of periodontal was worse in CHD with or without CP group than that in control group. The level of HDL-C was lower in CHD with CP group than that in control group, lower in CHD group than that in control group. The level of hs-CRP in CHD with CP group was the highest among the four groups and it was higher in CHD group and CP group than that in control group respectively. Condusion： hs-CRP and HDL may be the factors which make CP induce CHD, there may be a relationship between periodontal disease and CHD.

关 键 词：慢性牙周炎 冠心病 超敏C-反应蛋白 

分 类 号：R541.4[医药卫生—心血管疾病] R781.4[医药卫生—内科学]