2型糖尿病大血管病变患者瘦素和脂联素浓度变化及意义  

Clinical signifcance and changes of leptin and adiponectin concentration in type 2 diabetic patients with macrovascular pathological changes

作　　者：陈建悦[1] 汪大望[1] 朱麒钱[2] 裘国花[3] 章海凌[1] 

机构地区：[1]温州医学院第一附属医院内分泌科,浙江温州325000 [2]绍兴市人民医院内分泌科,浙江绍兴312000 [3]绍兴第二医院内分泌科,浙江绍兴312000

出　　处：《温州医学院学报》2008年第3期245-247,共3页Journal of Wenzhou Medical College

摘　　要：目的:探讨2型糖尿病合并大血管病变患者瘦素、脂联素浓度的变化及其临床意义。方法:采用ELISA法测定比较2型糖尿病合并大血管病变组47例和2型糖尿病无合并大血管病变组33例患者的瘦素、脂联素水平,其中大血管病变组分为3个亚组。结果:大血管病变组瘦素水平显著高于无大血管病变组(P<0.01);脂联素水平显著低于无大血管病变组(P<0.01)。不同部位大血管病变组间瘦素、脂联素水平差异无显著性。结论:血清瘦素水平增高、脂联素水平降低为2型糖尿病合并大血管病变的独立危险因素,血清瘦素水平增高、脂联素水平降低在2型糖尿病大血管病变从无到有的发生过程中起了重要作用。Objective： To investigate the clinical significance and changes of leptin and adiponectin concentration in type 2 cliabetes patients with macrovascular pathological changes. Methods： 80 patients with type 2 diabetes mellitus were divided into two groups： one group included 47 patients with macrovascular pathological changes and another group included 33 patients without macrovascular pathological changes. The serum concentration of leptin and adipenectin was detected in the two groups. Results： The leptin concentration was higher statistically in group with macrovascular pathological changes than that in the other one （P〈0.01）. However, the adipenectin concentration was lower statistically in group with macrovascular pathological changes than that in the other one （P〈0.01）. The serum concentration of leptin and adipenectin had no significant difference among the three subgroups of macrovascular pathological changes. Conclusion： High leptin concentration and low adiponectin concentration are two independent risk factors in type 2 diabetic patients with macrovascular pathological changes, and they play an important role in progressing the mcrovascular pathological changes in type 2 diabetic patients.

关 键 词：糖尿病 2型 瘦素 脂联素 糖尿病血管病变 

分 类 号：R587.1[医药卫生—内分泌]