正交设计法筛选丹皮酚-β-环糊精包合物工艺研究  

Study on Preparation Process of Paeonol-β-cyclodextrin Inclusion Compound by Orthogonal Design

作　　者：杨宗发[1] 江尚飞[1] 张荣发[1] 

机构地区：[1]重庆医药高等专科学校,重庆400030

出　　处：《中国药业》2008年第11期44-45,共2页China Pharmaceuticals

摘　　要：目的优选丹皮酚-β-环糊精包合物的制备工艺。方法采用正交试验法,以利用率和包封率为评价指标,筛选丹皮酚-β-环糊精包合物制备的最佳工艺条件。结果最佳制备工艺为1份丹皮酚、24份40%酒精、8份β-环糊精,超声处理时间为40min。结论该工艺合理、稳定可行,对丹皮酚-β-环糊精包合物的制备效率较高。Objective To optimize the preparation process of paeonol- β- cyclodextrin inclusion compound. Methods The optimum preparation process was selected with the orthogonal test. The optimal technological conditions were acquired by the evaluation of the availability and the encapsulation efficiencies. Results The optimal preparation conditions of paeonol- β- cyclodextrin inclusion compound were the proportion of paeonol,40% alcohol and paeonol- β- cyclodextrin（1：24： 8）. The ultrasounding time was 40 min. Conclusion The above preparation process gives the most rational, stable and feasible results, and increases the preparation efficiency of paeonol- β-cyclodextrin inclusion compound.

关 键 词：丹皮酚 正交试验 丹皮酚-β-环糊精包合物 

分 类 号：TQ460.6[化学工程—制药化工] R282.71[医药卫生—中药学]