Efficient synthesis of 4(3H)-quinazolinones using a soluble polymeric support  

作　　者：Chang Xie Hong Xia Li Ming Guo Liu Ming Wu Ding 

机构地区：[1]Key Laboratory of Pesticide ＆ Chemical Biology of Ministry of Education, Central China Normal University, Wuhan 430079, China

出　　处：《Chinese Chemical Letters》2008年第5期505-508,共4页中国化学快报（英文版）

基　　金：We gratefully acknowledge financial support of this work by the Natural Science Foundation of Hubei Province （No. 2006ABB016）; the National Natural Science Foundation of China （No. 20772041）; Key Project of Chinese Ministry of Education （No. 107082）.

摘　　要：4（3H）-Quinazolinones have been synthesized from poly（ethylene glycol） （PEG） supported aza-Wittig reaction. 2-Dialkylamino- 4（3H）-quinazolinones 6 were synthesized efficiently by reaction of secondary amine with PEG-supported carbodiimides 4, which were obtained from aza-Wittig reaction of PEG-supported iminophosphoranes 3 with isocyanates.4（3H）-Quinazolinones have been synthesized from poly（ethylene glycol） （PEG） supported aza-Wittig reaction. 2-Dialkylamino- 4（3H）-quinazolinones 6 were synthesized efficiently by reaction of secondary amine with PEG-supported carbodiimides 4, which were obtained from aza-Wittig reaction of PEG-supported iminophosphoranes 3 with isocyanates.

关 键 词：4（3H）-Quinazolinone Poly（ethylene glycol） supported Aza-Wittig reaction CARBODIIMIDE IMINOPHOSPHORANE 

分 类 号：O626[理学—有机化学]