Facile and efficient synthesis of 2-substituted-Nl-carbethoxy-2,3-dihydro-4(1H)-quinazolinones in fluorous solvent  

作　　者：Bai Ling Xu Jin Ping Chen Rong Zhang Qiao De Cai Fu 

机构地区：[1]lnstitute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100050, China [2]Hebei University of Science and Technology, Shijiazhuang 050018, China [3]Department of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China

出　　处：《Chinese Chemical Letters》2008年第5期537-540,共4页中国化学快报（英文版）

基　　金：We are grateful to the National Natural Science Foundation of China(No.30672540);the Natural Science Foundation of Beijing(No.7072048)for financial support.

摘　　要：A facile, efficient and novel approach to access 2-substituted-N1-carbethoxy-2,3-dihydro-4（1H）-quinazolinones was developed by condensation of substituted N-carbethoxyanthranilamide with alkyl, aromatic or heteroaromatic aldehydes in the refluxing 2,2,2- trifluoroethanol or hexafluoroisopropanol using p-toluenesulfonic acid as catalyst.A facile, efficient and novel approach to access 2-substituted-N1-carbethoxy-2,3-dihydro-4（1H）-quinazolinones was developed by condensation of substituted N-carbethoxyanthranilamide with alkyl, aromatic or heteroaromatic aldehydes in the refluxing 2,2,2- trifluoroethanol or hexafluoroisopropanol using p-toluenesulfonic acid as catalyst.

关 键 词：QUINAZOLINONES TRIFLUOROETHANOL HEXAFLUOROISOPROPANOL Fluorous solvent Solvent effect 

分 类 号：O626[理学—有机化学]