Indirect determination of cefradine with n-propyl alcohol-ammonium sulfate-water system by extraction-flotation of cuprous thiocyanate  

作　　者：Ling Li Wu Wei Zhao Quan Min Li 

机构地区：[1]College of Chemistry and Environmental Science, Henan Normal University,The Key Laboratory of Environmental Pollution Control Technology of Henan province, Xinxiang 453007, China [2]Henan Radio and Television University, Zhengzhou 450008, China

出　　处：《Chinese Chemical Letters》2008年第5期565-568,共4页中国化学快报（英文版）

摘　　要：A new method was developed for the determination of cefradine by extraction-flotation of CuSCN. The experiment indicated that in the presence of 0.20 mol/L NaOH the degradation of cefradine took place in water bath at 100 ℃. The thiol group （-SH） of the degradation product could reduce Cu（Ⅱ） to Cu（Ⅰ） for the formation of the emulsion CuSCN in the presence of NH4SCN at pH 4.0. By determining the residual amount of Cu（Ⅱ） in the solution and calculating the flotation yield of Cu（Ⅱ）, the indirect determination of cefradine can be obtained. This method has been applied to determine cefradine in capsules, human serum and urine samples, respectively.A new method was developed for the determination of cefradine by extraction-flotation of CuSCN. The experiment indicated that in the presence of 0.20 mol/L NaOH the degradation of cefradine took place in water bath at 100 ℃. The thiol group （-SH） of the degradation product could reduce Cu（Ⅱ） to Cu（Ⅰ） for the formation of the emulsion CuSCN in the presence of NH4SCN at pH 4.0. By determining the residual amount of Cu（Ⅱ） in the solution and calculating the flotation yield of Cu（Ⅱ）, the indirect determination of cefradine can be obtained. This method has been applied to determine cefradine in capsules, human serum and urine samples, respectively.

关 键 词：CEFRADINE Copper（Ⅱ） n-Propyl alcohol EXTRACTION-FLOTATION 

分 类 号：O627[理学—有机化学] O658.2[理学—化学]