基于虚拟切片的体视学模型仿真与分析  

Simulation and data analysis of stereological modeling based on virtual slices

作　　者：王灏[1] 申洪[1] 白晓燕[1] 

机构地区：[1]南方医科大学病理学教研室,广东广州510515

出　　处：《南方医科大学学报》2008年第5期767-769,773,共4页Journal of Southern Medical University

基　　金：国家自然科学基金(30271462);广东省科技攻关计划(2KM04501S);广州市科技攻关重点项目(2003Z2-E0061;E0062)~~

摘　　要：目的建立虚拟组织切片的体视学模型,并以软件系统作为实现手段,模拟虚拟切片过程,为体视学的理论提供一个客观实证工具。方法以数学手段描述组织切片可能出现的二维形态特征,模拟切片过程,将所得到的数据进行数值分析,与经验公式进行了拟合比较。结果基于此算法可实现虚拟随机模拟切片,经拟合优度检验数据分布的均匀性检验通过率达94.5%以上,独立性检验通过率达92%以上,且均符合正态性要求。经线性和曲线拟合能够得到与经验公式相一致的体视学参数相关关系。结论本文所述算法具有可行性,可以反映数值模拟结果的正确性。Objective To establish a computer-assisted stereological model for simulating the process of slice section and evaluate the relationship between section surface and estimated three-dimensional structure. Methods The model was designed by mathematic method as a win32 software based on the MFC using Microsoft visual studio as IDE for simulating the infinite process of sections and analysis of the data derived from the model. The linearity of the fitting of the model was evaluated by comparison with the traditional formula. Results The win32 software based on this algorithm allowed random sectioning of the particles distributed randomly in an ideal virtual cube. The stereological parameters showed very high throughput （〉94.5% and 92%） in homogeneity and independence tests. The data of density, shape and size of the section were tested to conform to normal distribution. The output of the model and that from the image analysis system showed statistical correlation and consistency. Conclusion The algorithm we described can be used for evaluating the stereologic parameters of the structure of tissue slices.

关 键 词：虚拟现实 三维仿真 体视学 线性拟合 

分 类 号：R319[医药卫生—基础医学]