下肢静脉性溃疡RANTES的表达  

RANTES expression in venous ulceration of lower limbs

作　　者：陈流华[1] 叶财盛[1] 殷恒讳[1] 叶洁莲[1] 王深明[1] 

机构地区：[1]中山大学附属第一医院血管外科,广东广州510080

出　　处：《南方医科大学学报》2008年第5期861-862,共2页Journal of Southern Medical University

摘　　要：目的探讨RANTES在下肢静脉性溃疡的表达及意义。方法采用半定量RT-PCR方法检测下肢静脉溃疡患者、单纯下肢静脉功能不全患者和健康人下肢外周血RANTES mRNA的表达。结果溃疡组血液RANTES mRNA的表达与无溃疡组和对照组相比有显著性差异(P<0.01);无溃疡组和对照组相比有显著性差异(P<0.01)。结论RANTES mRNA高表达可能是下肢静脉性溃疡发病机制之一。Objective To investigate the expression of RANTES in, venous ulceration. Methods From patients with lower limb venous ulceration, patients with non-ulcerous venous insufficiency, and healthy individuals, peripheral blood was collected from the lower limb veins for measurement of RANTES mRNA using RT-PCR. Results In the ulceration group, the expression ofRANTES mRNA was significantly increased as compared with the other two groups （P〈0.01）. RANTES mRNA expression was also significant higher in the non-ulcerous group than the control group （P〈0.01）. Conclusion High expression ofRANTES mRNA may be one of the important mechanisms of venous ulceration.

关 键 词：RANTES 静脉功能不全 静脉性溃疡 

分 类 号：R654.4[医药卫生—外科学]