2型糖尿病家系成员患病特征的现况研究  

Cross-sectional Study on Prevalence of Type 2 Diabetes among Family Members

作　　者：金英良[1] 高晓虹[2] 高政南[3] 程然[2] 张翠丽[2] 李晓枫[2] 马莉[2] 

机构地区：[1]徐州医学院,江苏徐州221002 [2]大连医科大学,辽宁大连116044 [3]辽宁省大连市中心医院,辽宁大连116021

出　　处：《预防医学论坛》2008年第5期393-395,共3页Preventive Medicine Tribune

基　　金：国家"863"计划资助项目;项目编号:2002AA223031

摘　　要：[目的]了解2型糖尿病（糖尿病）核心家系成员糖尿病患病特点和遗传特征。[方法]对2003-2005年在大连医科大学附属一院等医院门诊住院及接受健康教育的糖尿病患者中有家族史的患者及其家庭成员进行调查。[结果]调查91个家系的305人。糖尿病患病率,男性（132人）为45.45%,女性（173人）为51.45%（P〉0.05）;母亲患糖尿病者的子女（90人）为17.78%,父亲患糖尿病者的子女（52人）为23.08%（P〉0.05）;患病率与年龄呈正相关（P〈0.05）;家系一级亲属中,TC、TG、LDL-C、HDL-C中有1项或1项以上异常者所占比例,NGT组为64.71%,IGR组为54.05%,糖尿病组为70.68%（P〉0.05）。[结论]大连地区有家族史的糖尿病核心家系成员糖尿病患病率在性别、父母单方患病者子女之间无差异,随年龄的增加而增高;一级亲属中糖耐量正常者已出现血脂代谢紊乱。[Objective]In order to study epidemiological and hereditary features of type 2 diabetes mellitus（T2DM）families. [Methods]Outpatients,inpatients or the subjects received health education on T2DM from 2003 to 2005 in the first affiliated hospital of Dalian Medical University and their family members were investigated. [Results]305 people from 91 families were investigated. The morbidity was 45.45% in 132 male and 51.45% in 173 female （ P〉0.05）;the morbidity in offspring born from mothers with T2DM was 17.78%, while father with T2DM, the morbidity of his offspring was 23.08%（ P 〉0.05） ;there was positive relation between age and prevalence （ P 〈0.05）;one or more items of TC,TG, LDL-C,HDL-C were abnormality, the rate of abnormality was 64. 71% in NGT, 54.05% in IGR, 70.68% in T2DM. [Conclusion]There was no difference in the morbidity in male and female as well as in offspring whose father or mother had diabetes mellitus are in Dalian,and the prevalence increased with the increase of age;Blood lipid metabolic disorder was found in direct-related members with normal glucose tolerance.

关 键 词：2型糖尿病 患病 家系 血脂 

分 类 号：R587.1[医药卫生—内分泌]