FADD、Caspase-3与稽留流产的关系探讨  

The relationship between the expressions of FADD,Caspase-3 and missed abortion

作　　者：彭诗维[1] 谭布珍[1] 李里香[2] 汪庆余[2] 雷瑛[2] 

机构地区：[1]南昌大学第二附属医院妇产科,江西330006 [2]南昌大学第二附属医院病理科,江西330006

出　　处：《中国优生与遗传杂志》2008年第6期66-67,共2页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨FADD及Caspase-3在稽留流产绒毛滋养细胞中的表达及其关系。方法随机选取早孕稽留流产组35例(实验组)和正常早孕绒毛组30例的绒毛(对照组)检测两组绒毛滋养层细胞FADD和Caspase-3表达。结果FADD和Caspase-3在两组滋养层细胞中均有阳性表达,表达部位均以合体滋养层细胞为主。FADD和Caspase-3在稽留流产组绒毛滋养细胞中表达明显强于对照组,差异有显著性意义(P<0.01)。结论Fas凋亡途径可能是滋养层细胞凋亡的主要凋亡途径,FADD、Caspase-3是滋养层细胞凋亡中重要的促凋亡因子,滋养层细胞凋亡的增加可能参与了稽留流产的发生。Objective ： To investigate the expression of FADD and Caspase -3 and association between them in placental trophoblastic cells of missed abortion, Methods ： Immunohistochemistry was empolyed on two groups of 30 samples of surgical aspiration （control group） and 35 samples of missed abortion （missed abortion group） were random selected and studied. To show the expression of FADD and Caspase - 3. Results： There were positive expression of FADD and Caspase - 3 in trophoblastic cells in two groups. There were no difference in the localization of FADD and Caspase - 3 expression between two groups, principally in the syncytrophoblastic layer, The expression of FADD and Caspase -3 in trophoblastic cells in missed abortion group was significantly increased compared with that in control group （ P 〈0, 01 ）. Conclusion ： Fas - mediated pathway may be the primary apoptotic pathway in trophoblastic cells. FADD and Caspase -3 could play an important role in the apoptosis of trophoblastic cells. The increment of apoptosis may be play a important role in missed abortion.

关 键 词：滋养细胞 凋亡 稽留流产 FADD CASPASE家族 

分 类 号：R714.21[医药卫生—妇产科学]