复方环磷腺苷乳膏对豚鼠皮肤刺激性实验观察  

Experimental Investigation on Skin Irritation Induced by Compound Cream of Adenosine Cyclophosphate in Guinea Pigs

作　　者：严霞[1] 盛国荣[2] 

机构地区：[1]江苏省南通市皮肤病性病防治所护理部,226006 [2]江苏省南通市皮肤病性病防治所药剂科,226006

出　　处：《医药导报》2008年第6期621-622,共2页Herald of Medicine

基　　金：江苏省南通市社会发展科技计划基金资助项目(基金编号:S2006029)

摘　　要：目的对复方环磷腺苷乳膏进行豚鼠皮肤刺激性实验,以了解其安全性。方法以一次给药和多次给药方法,将复方环磷腺苷乳膏外涂于白色豚鼠背部正常或破损去毛区皮肤,观察皮肤刺激性反应。结果复方环磷腺苷乳膏对豚鼠正常皮肤平均反应分值均<0.50分,对豚鼠破损皮肤平均反应分值在给药后1和24h均>0.50分,但<3.00分,48h后平均反应分值均<0.50分。结论复方环磷腺苷乳膏对豚鼠正常皮肤无刺激性,对破损皮肤有轻度刺激性,但给药48h后,这种刺激性消失。Objective To study the safety of compound cream of adenosine cyclophosphate by evaluating the skin irritation in guinea pigs . Methods Compound cream of adenosine cyclophosphate was spreaded on the normal or damaged derma of animal back once or repetitiously and observe the situation of irritation. Results The average reaction value of compound cream of adenosine cyclophosphate in normal skin was lower than 0.50, and from 0.50 to 3.00 in damaged skin after 1 and 24 h, but lower than 0.50 after 48 h. Conclusion Compound cream of adenosine cyclophosphate had no irritation to normal skin and a modest stimulation to the damaged skin, but with a less than 48 h duration.

关 键 词：环磷腺苷乳膏 复方 皮肤刺激性 

分 类 号：R986[医药卫生—药品] R965.3[医药卫生—药学]