加替沙星序贯疗法对老年社区获得性肺炎的疗效评价  

A Clinical Evaluation of Gatifloxacin Sequential Therapy for the Elderly Patients with Community-acquired Pneumonia

作　　者：袁鸿绯[1] 吴海鸰[1] 叶丽君[1] 

机构地区：[1]浙江省台州医院门诊部,317000

出　　处：《医药导报》2008年第6期667-669,共3页Herald of Medicine

摘　　要：目的评价加替沙星序贯疗法对老年社区获得性肺炎的临床疗效。方法老年社区获得性肺炎患者246例,分为治疗组120例和对照组126例,治疗组先给予加替沙星400mg(250mL)静脉滴注,qd,3～5d后改加替沙星400mg,qd,po,总疗程7～10d;对照组给予加替沙星400mg(250mL)静脉滴注,qd,7～10d。治疗期间两组均不使用其他抗菌药。结果治疗组和对照组有效率分别为98.33%,94.44%(P>0.05)。细菌清除率分别为91.67%,87.84%(P>0.05)。结论加替沙星序贯疗法治疗老年社区获得性肺炎安全、有效、经济、方便。Objective To evaluate the clinical efficacy of gatifloxaein sequential therapy for the elderly patients with community-acquired pneumonia （CPA）. Methods Two-hundred and forty-six patients were divided into two groups ： treatment group with 120 cases assigned by gatifloxacin for intravenous injection once daily 400 mg for 3 - 5 days and then with oral gatifloxacin 400 mg once daily, and control group with 126 cases treated by gatifloxacin for intravenous injection once daily 400 rag. The overall period of treatment was 7- 10 days . The patients from two groups were not given any other antibiotics. Results The total effective rate of the treatment group was higher , compared with control group （98.33% vs 94.44% , P 〉 0.05） , but no obvious differences of bacteria clearance rate was observed in the two groups （ P 〉 0.05 ）. Conclusion Gatifloxacin sequential therapy offered a safety, utility,strategy for elderly patients of CPA .

关 键 词：加替沙星 序贯疗法 肺炎 社区获得性 老年 

分 类 号：R978.19[医药卫生—药品] R563.1[医药卫生—药学]