β环糊精包合血竭对血栓形成和TXB_2/6-Keto-PGF_(1α)水平的影响  

Effects of β-cyclodextrin Inclusion of Dragon's Blood on Thrombosis and TXB_2/6-Keto-PGF_(1α)

作　　者：杨丽川[1] 陈鹏[2] 胡建林[1] 雷伟亚[2] 陈植和[2] 沈志强[2] 

机构地区：[1]昆明医学院药学院 [2]云南省天然药物药理重点实验室,云南昆明650031

出　　处：《昆明医学院学报》2008年第2期1-4,共4页Journal of Kunming Medical College

基　　金：国家自然基金资助项目(30660212)

摘　　要：目的探讨血竭β环糊精包合血竭对血栓形成作用机制.方法电刺激大鼠颈动脉血栓形成方法评价包合-PGF1α水平.结果包合血竭对电刺激大鼠颈动脉引起的血栓有明显的对抗作用,体内外均显著抑制花生四烯酸(AA)诱导的家兔血小板聚集,并降低家兔血浆TXB2含量,升高6-Keto--PGF1α水平.结论包合血竭抗血栓形成作用与抑制花生四烯酸(AA)代谢有关.Objective To reaearch antithrombosis and antiplatelet mechanism of β -cyclodextrin inclusion of Dragon＇s Blood. Methods Electrically stimulated arterial thrombosis in rats was used to evaluate the antithrombotic effects of β -cyclodextrin inclusion of Born＇s method. Immunoassay of TXB2 and 6 - keto - Results Dragon＇s Blood, Platelet aggregation was tested according to PGF1 level was conducted by the method of Terashita et al β-cyclodextrin inclusion of Dragon＇s Blood significantly protected against thrombosis caused by electrical stimulation on rats. In vitro and vivo, β -cyclodextrin inclusion of Dragon＇s Blood markedly inhibited AA -induced platelet aggregation. And significantly decreased plasma TXB2 level while increased that of 6-Keto-prostaglandinF1α. Conclusion The antithrombotic effects of β-cyclodextrin inclusion of Dragon＇ s Blood is mainly associated with the influence platelet arachidonic acid （AA） metabolism.

关 键 词：包合血竭 血栓形成 血栓素B2(TXB2) 6-酮-前列腺素F1Α 

分 类 号：R973[医药卫生—药品]