组织因子(TF)与弥散性血管内凝血(DIC)  

Tissue Factor (TF) and Disseminated Intravascular Coagulation (DIC)

作　　者：谢军[1] 

机构地区：[1]中山大学中山医学院,广州510080

出　　处：《中山大学研究生学刊（自然科学与医学版）》2008年第1期8-14,共7页Journal of the Graduates Sun YAT-SEN University(Natural Sciences.Medicine)

摘　　要：弥散性血管内凝血是一种并不罕见的获得性临床综合症,常继发于其它许多疾病,以全身凝血纤溶系统功能紊乱为特征,并最终因广泛出血和多器官功能衰竭而死亡。组织因子是外源性凝血途径的启动因子,近几年研究发现,组织因子的激活在弥散性血管内凝血的发生中起了关键作用,因此了解组织因子与弥散性血管内凝血的关系,对于防治弥散性血管内凝血有重大意义,本文就组织因子与弥散性血管内凝血的研究进展做一简要综述。Disseminated Intravascular Coagulation is not a scarcely happened acquired syndrome in clinic, and is usually secondary to an underlying disorder. It is characterized by systemic derangement of the blood coagulation and fibrinolysis system and usually ended in systematically bleeding and multiple organ failure. Tissue fac- tor is the initiation factor of extrinsic coagulation pathway. Recent research find that tissue factor plays a central role in the initiation of disseminated intravascular coagulation. Understanding the relationship between tissue factor and disseminated intravascular coagulation is very important for prevention and cure this syndrome. This article provides a brief introduction of tissue factor and disseminated intravascular coagulation.

关 键 词：弥散性血管内凝血 组织因子 外源性凝血途径 多器官功能衰竭 

分 类 号：Q42[生物学—神经生物学] S852.44[生物学—生理学]