肾素-血管紧张素-醛固酮系统基因多态性与心房颤动  

Renin-Angiotensin-Aldosterone System Gene-Polymorphisms and Atrial Fibrillation

作　　者：张复贵[1,2] 曾秋棠[1] 闵新文[2] 

机构地区：[1]华中科技大学同济医学院附属协和医院心内科,湖北武汉430022 [2]东风公司总医院心内科,湖北十堰442000

出　　处：《心血管病学进展》2008年第B05期29-31,共3页Advances in Cardiovascular Diseases

摘　　要：心房颤动(房颤)的病因多认为是由心脏的组织结构及电活动的改变引起,近年来研究表明遗传因素也可能参与了房颤的发生:家族性房颤的遗传背景已较明确;非家族性房颤遗传因素的相关研究也取得了进展,其中肾素-血管紧张素-醛固酮系统基因多态性与房颤的相关性研究就取得了部分进展。有研究认为血管紧张素原基因多态性及血管紧张素转换酶基因多态性与房颤的发病有关,但也有相反观点;而血管紧张素受体基因多态性则多认为与房颤的发病无关;肾素和醛固酮合酶的基因多态性与房颤的相关性问题尚无明确报道。It is considered that atrial fibrillation was caused by the change of heart＇ s tissue structure and electric activity, and the study has indicated that genetic factor was involved in the atrial fibrillation for the last few years, especially, genetic background of familial＇ s atrial fibrillation was obvious. The related study of non-familial＇ s atrial fibrillation has also made some progress, above all, the study on atrial fibrillation and renln-angiotensin-aldosterone system gene-polymorphisms has acquired some progress. Polymorphisms of the angiotensinogen gene and angiotensin-convertion enzyme gene have been shown to be involved in the occurrence of atrial fibrillation in many studies, but opposite viewpoint has also exised. Polymorphism of the angiotensin receptor gene is not associated with the occurrence of atrial fibrillation ,the correlated research on atrial fibrillation and polymorphism of the renin gene and aldosterone synthase gene has not yet reported.

关 键 词：肾素-血管紧张素-醛固酮系统 基因多态性 心房颤动 

分 类 号：R541.75[医药卫生—心血管疾病]