宫内不良环境与慢性成年疾病关系的研究进展  

Progress of Relationship Between Adverse Intrauterine Environment and Chronic Adult Diseases

作　　者：杨景阳[1] 黄子扬[1] 

机构地区：[1]福建医科大学附属第二医院心内科,福建泉州362000

出　　处：《心血管病学进展》2008年第B05期103-106,共4页Advances in Cardiovascular Diseases

摘　　要：不良宫内环境与多种慢性成年疾病相关的学说已在许多国家的研究中得到初步证实。这些疾病包括:心脏病,高血压,2型糖尿病和胰岛素抵抗,脑卒中,高胆固醇血症和凝血功能障碍等。营养不良、贫血和缺氧等宫内不良因素可能通过多种机制程序控制胎儿的生长发育,进而对出生后产生长时间甚或终身的影响。现综述近年来宫内不良环境与多种慢性成年疾病的关系及其相关机制的研究进展。Many studies have shown that adverse intrauterine environment had been associated with an increased incidence of various adult chronic diseases, including heart disease, hypertension, type 2 diabetes, insulin resistance, stroke, hypercholesterolemia and coagulation disorders. Adverse intrauterine environment,such as malnutrition,anemia and hypoxia,may programme fetal growth and development through various mechanisms,and may also underlie longer-term or life-long effects after birth. This paper reviews recent progress on the studies of the relationship between adverse intrauterine environment and chronic adult diseases and their related mechanisms.

关 键 词：营养不良 疾病胎儿起源假说 

分 类 号：R714.2[医药卫生—妇产科学] R714.7[医药卫生—临床医学]