泮托拉唑对腹部手术后应激性溃疡的预防作用  

The Preventive Effect of Pantoprazole on Stress Ulcer after Abdominal Operation

作　　者：江腾[1] 黄家良[1] 曹传培[1] 唐志国[1] 

机构地区：[1]九江学院附属医院普外科,江西九江332000

出　　处：《赣南医学院学报》2008年第2期219-220,236,共3页JOURNAL OF GANNAN MEDICAL UNIVERSITY

摘　　要：目的：探讨泮托拉唑在预防腹部手术后并发应激性溃疡中的作用。方法：选择具有高危因素的腹部手术后患者80例，随机分治疗组40例，给予泮托拉唑40mg静脉滴注。对照组40例，给予西咪替丁800mg静脉滴注。两组均每天1次，连用7-10d；观察两组疗效。结果：治疗组与对照组发生应激性溃疡分别为1例（2．5％）和8例（20％），差异有显著性（P〈0．05）。结论：泮托拉唑能有效预防腹部手术后并发应激性溃疡。Objective： To evaluate the effect of pantoprazole in preventing stress ulcer hemorrhage after abdominal operation. Method：80 patients with dangerous factors after abdominal operation were divided into two groups ：40 patients of pantoprazole therapy group received pantoprazole 40mg, iv gtt, qd, persisting for 7 ～ 10 day. 40 patients of cimetidine control group received cimetidine 800mg,iv gtt,qd,persisting for 7 ～ 10 day;to observe the therapeutic effect. Results：the rates of stress ulcer hemorrhage among the two groups were 2.5% in pantoprazole therapy group and 20% in cimetidine control group, there was significant difference between the two groups（P 〈 0. 05 ）. Conclusion： Pantoprazole has significant beneficial effect in preventing stress ulcer hemorrhage after abdominal operation.

关 键 词：泮托拉唑 西咪替丁 应激性溃疡 

分 类 号：R969.4[医药卫生—药理学]