孕妇与新生儿凝血酶原前体蛋白水平及相互关系的研究  

Levels of(protein-Ⅱ induced by vitamin K absence,PIVKA-Ⅱ)in newborns and its relationship with their pregnant women

作　　者：杨善浦 董虹[2] 吴月超 李素琴[3] 龚爱敏 罗春林[3] 吴叶健 陈松德 

机构地区：[1]玉环县人民医院儿科,317600 [2]玉环县人民医院检验科,317600 [3]玉环县人民医院妇产科,317600

出　　处：《浙江医学》2008年第5期442-443,446,共3页Zhejiang Medical Journal

摘　　要：目的探讨孕妇与新生儿脐血凝血酶原前体蛋白(PIVKA-Ⅱ)水平及其相互关系。方法采集在本院住院待产的74名健康孕妇静脉血及其新生儿脐血,用双抗夹心ELISA法测定孕妇静脉血及新生儿脐血PIVKA-Ⅱ水平,>2ng/ml为PIVKA-Ⅱ阳性。结果74名孕妇PIVKA-Ⅱ阳性仅1例,阳性率为1.4%。74名孕妇分娩的新生儿(每一对双胞胎按1例计)脐血标本中,PIVKA-Ⅱ阳性33例,阳性率为44.6%,其中足月单胎新生儿占31例。仅1例PIVKA-Ⅱ阳性孕妇其新生儿脐血PIVKA-Ⅱ为阴性,33例脐血PIVKA-Ⅱ阳性的新生儿母亲PIVKA-Ⅱ均为阴性。结论新生儿普遍存在亚临床维生素K(VitK)缺乏现象,而且不能以孕妇PIVKA-Ⅱ水平推断新生儿实际的VitK营养状况。Objective To investigate the levels of protein-ll induced by vitamin K absence （PIVKA-ll） in umbilical cord blood and related pregnant women. Methods PIVKA-ll levels of 74 healthy pregnant women and their newborns was measured by enzyme-linked immunesorbent assay （ELISA）. PIKVA-ll 2ng/ml was set as cut-off level. Results Only one out of 74 pregnant women showed positive serum PIVKA-ll with a positive rate of 1.4% （1/74）, however, the newborn of this positive case had negative PIVKA-ll in umbilical cord blood. Thirty three out of 74 newborns had positive PIVKA-ll with a positive rate of 44.6% （33/74）, but their mothers all had negative serum PIVKA- ll. Conclusion The results indicate that the sub-clinical status of vitamin K deficiency was common in the neonates, and the vitamin K nutrition condition of newborns could not inferred from PIVKA- ll levels of the pregnant women.

关 键 词：凝血酶原前体蛋白 维生素K缺乏 孕妇 新生儿 

分 类 号：R446.6[医药卫生—诊断学]