曙红Y共振光散射法测定双嘧达莫  

Determination of Dipyridamole with Eosin Y by a Resonance Light-Scattering Method

作　　者：赵小辉[1] 牛卫芬[1] 

机构地区：[1]长江师范学院化学及环境科学系,重庆涪陵408003

出　　处：《应用化学》2008年第6期693-696,共4页Chinese Journal of Applied Chemistry

基　　金：教育部春晖计划(渝教外:[2005]7-24)

摘　　要：在pH=1.98缓冲溶液中,双嘧达莫可与染料探针曙红Y通过相互结合,产生以315nm为特征峰的共振光散射(RLS)增强信号。在该特征波长下测定的增强共振光散射强度(ΔIRLS)与双嘧达莫浓度在一定范围内呈线性关系,据此建立了测定痕量双嘧达莫的共振光散射法。当曙红Y的浓度为3.0×10-5mol/L时,双嘧达莫的检出限可达16.1nmoL/L。同时进行了实际样品的测定,相对标准偏差在1.3%~2.5%之间,回收率为(99.2±3.3)%^(102.0±1.7)%。In pH = 1.98 buffer solution, dipyridamole associates with eosine Y and produces a greatly enhanced resonance light scattering（RLS） signals at 315 nm. It was found that the enhanced RLS intensity （ △IRLS ） at 315 nm is proportional to the concentration of dipyridamole, and thus a new method for determining trace dipyridamole has been established accordingly. This method has an advantage of simplicity in experimental operation and conditon. The determination limit of dipyridamole is 16. 1 nmol/L when the concentra- tions of cosine Y is 3.0 × 10^-5 moL/L. Simultaneously this method has been successfully applied to the actual samples, and the relatively standard deviation between 1.3% - 2.5%, the recovery rate of actual sample is about （99.2 ± 3.3 ） % - （ 102. 0 ± 1.7） %, indicating that this analysis method has the good determination accuracy and the reliability.

关 键 词：双嘧达莫 曙红Y 共振光散射 

分 类 号：O655[理学—分析化学]