蟾酥、蟾皮、蟾衣提取物对心肌细胞膜ATP酶的影响  

Effect of Extraction from Toad Cake,Toad-cortex and Bufonic on ATP Enzyme of Myocardium Membrane

作　　者：陈才法[1] 缪进[1] 李景辉[1] 郑维发[1] 邹寿昌[2] 

机构地区：[1]江苏省药用植物生物技术重点实验室,徐州师范大学,江苏徐州221116 [2]徐州师范大学生命科学学院

出　　处：《四川动物》2008年第3期393-395,共3页Sichuan Journal of Zoology

基　　金：江苏省自然科学基金项目(No.99KJB360009)

摘　　要：用中华大蟾蜍蟾酥、蟾皮、蟾衣脂溶性及水溶性提取物研究其对小鼠心肌细胞膜Na+-K+-ATP酶、Ca2+-ATP酶和Mg2+-Ca2+-ATP酶活性影响,同时以华蟾素注射液为对照。结果表明:所有提取物均可抑制心肌细胞膜的上述3种ATP酶活性,其中对Na+-K+-ATP酶抑制作用较强的有蟾皮脂溶性和蟾酥脂溶性成分,对Ca2+-ATP酶和对Mg2+-Ca2+-ATP酶的影响结果相类似,作用较强的有蟾皮水溶性成分和华蟾素。The experimentstudied the influence on the activity of Na^＋-K^＋-ATPase, Ca^2＋-ATPase and Mg^2＋-Ca^2＋-ATPase in myocardium membrane of the mouse by the extracts of toad-cake, toad-cortex and toad-ecdysis, and in the meantime cinobufagin was applied as control. The results indicated that all extracts could repress the cardiac muscle cell membrane of above-mentioned three species ATP enzymatic activities. The liposoluble extractsof toad cake and toad-cortex had stronger inhibition action of Na^＋-K^＋-ATPase than other extracts. The influence effect of the Ca^2＋-ATPase and Mg^2＋- Ca^2＋-ATPase was similar. The action of water soluble of toad-cortex and cinobufagin revealed stronger than that of other extracts.

关 键 词：蟾酥 蟾衣 蟾皮 NA^+-K^+-ATP酶 CA^2+-ATP酶 Mg^2+-Ca^2+-ATP酶 

分 类 号：R285[医药卫生—中药学]