NIPAAm系互穿网络凝胶的合成及载药释药性能研究  

Synthesis of IPN Hydrogels Based on N-Isopropylacrylamide and Its Drug Loading and Unloading Property

作　　者：潘春跃[1] 隆清德[1] 饶燕平[1] 张报进[1] 许晨曦[1] 

机构地区：[1]中南大学化学与化工学院,湖南长沙410083

出　　处：《广州化学》2008年第2期37-43,共7页Guangzhou Chemistry

摘　　要：合成了三种亲疏水性不同的温度及pH敏感的PAAc/P(NIPAAm-co-BMA)、PAAc/PNIPAAm和PAAc/P(NIPAAm-co-AAm)互穿网络(IPN)水凝胶,以水杨酸钠和水杨酸为模型药物,研究了温度、pH值及药物和凝胶的亲疏水性相互作用对模型药物释药性能的影响。研究结果表明,随着凝胶亲水性的增强,水杨酸钠的载药率提高,释药率也越大;相反疏水性增强也有利于提高水杨酸的载药率;IPN凝胶在水中的释药过程属于溶胀支配型释放,药物释放率随凝胶的亲水性增强而增强,同时,载药凝胶在45℃水中的释药率大于25℃时的释药率。在25℃时,水杨酸在pH=2.2的缓冲溶液中几乎不释放,而在pH=7.4的缓冲溶液中能以较快的速率释放。Three kinds of temperature and pH sensitive interpenetrating networks hydrogels, PAAc / P（NIPAAm-co-BMA）, PAAc / PNIPAAm and PAAc / P（NIPAAm-co-AAm）, with different hydrophilicity were prepared. With sodium salicylate and salicylic acid as model drug, the influence of temperature, pH and hydrophilicity/hydrophobicity of hydrogel to the loading and release ratio of model drug was studied. The results showed that incorporation of hydrophobic BMA polymer into PAAc/PNIPAAm would increase the loading efficiency of salicylic acid while the hydrophilic AAm would increase loading efficiency of sodium salicylate. The drug delivery system belongs to swelling-dependence. The more the hydrophilic of a gel, the more the release ratio. The releasing ratio of the drug-loaded IPN gels at 45℃ was higher than that at 25℃. Also pH values had a great impact on the release ratio; salicylic acid was almost not released at pH= 2.2 whereas released faster at pH = 7.4.

关 键 词：N-异丙基丙烯酰胺 丙烯酰胺 甲基丙烯酸丁酯 IPN凝胶 药物控制释放 

分 类 号：O623.626[理学—有机化学]