河北省鼠疫自然疫源地人群血清鼠疫F1抗体流行病学调查  

Epidemiological investigation on plague F1 antibody of human serum in plague natural foci of Hebei province

作　　者：杜国义[1] 史献明[1] 董国润[1] 刘合智[1] 李玉贵[1] 白万翔[1] 乔峰 张月枝[1] 杨顺林[1] 郑金萍 杨建民 齐继东 高少坤 胡乐乐[1] 杨小燕[1] 白晓英[1] 白雪薇[1] 刘卫霞 

机构地区：[1]河北省鼠疫防治所检验科,张家口075000 [2]河北省康保县疾病预防控制中心 [3]河北省蠡县疾病预防控制中心 [4]张家口市桥西区医院

出　　处：《中国媒介生物学及控制杂志》2008年第3期246-248,共3页Chinese Journal of Vector Biology and Control

基　　金：河北省2007年医学科学研究重点课题(07020)

摘　　要：目的调查河北省鼠疫自然疫源地人群F1抗体的三间分布情况和维持机制。方法在河北省历史人间鼠疫发生地和动物间鼠疫活动疫源地的2个镇3个行政村采集居民血样196份作为调查对象,采集非疫区的居民血样100份作为对照组。同时进行常规的鼠疫间接血凝试验和鼠疫F1抗体胶体金试验。结果通过对历史疫区和动物间鼠疫流行活动疫源地的196份居民血清检测,阳性4份,阳性率为2.04%。间接血凝试验阳性4份,金标试验阳性3份;非疫区居民血清2种试验全部为阴性。经统计学检验,疫区居民鼠疫F1抗体阳性率和非疫区F1抗体阳性率差异有统计学意义(χ2=0.822,P<0.05)。2种试验方法的阳性率无统计学意义。结论目前,在河北省鼠疫自然疫源地内尚存在一定比例的鼠疫F1抗体阳性人群,具体原因需做进一步的调查分析。Objective To study the three-dimensional distribution and maintenance mechanisms of plague F1 antibody of healthy population in the plague natural loci of Hebei province. Methods To sample 196 blood samples from three administrative villages belonging to plague natural foci formerly, and collect 100 blood samples from non-infected areas as the control. Indirect hernagglutination test（IHA） and collocdal gold immunobinding were used in this test. Results There were 4 positive among 196 blood samples, and the positive rate was 2.04%. There were 4 positive samples in IHA and 3 positive samples in colloedal gold immunobinding. The human serums collected from non-infected areas were all negative after tested by theses two methods. There was significant difference between the positive rate of F1 antibody in epidemic areas and the positive rate of F1 antibody in non-epidemic areas （X2 = 0. 822, P〈 0.05）. Conclusion At present, there are still a number of F1 antibody positive population in the natural epidemic focus of Hebei, and it needs further investigation and analysis to clarify.

关 键 词：鼠疫 F1抗体 流行病调查 隐性感染 

分 类 号：R254.8[医药卫生—中医内科学]