Sonoclot凝血及血小板功能分析仪在体外循环中的应用  

The application of Sonoclot, a coagulation and platelet function analysis system in cardiopulmonary bypass surgery

作　　者：周萍[1] 姜萍[1] 陆静[1] 

机构地区：[1]广东医学院附属医院,湛江524001

出　　处：《国际护理学杂志》2008年第6期612-613,共2页international journal of nursing

摘　　要：目的采用Sonoclot凝血及血小板功能分析仪观察135例体外循环（CPB）心脏手术的凝血状况，以探讨其临床价值。方法选择CPB下的心脏手术患者135例，分别在麻醉前、手术开始后而CPB前（未肝素化）以及鱼精蛋白中和肝素后采静脉血。用Sonoclot凝血及血小板功能分析仪检测全血激活时间（ACT）、凝血速率（Clot Rate，CR）和血小板功能（Platelet Function，PF）；同时用常规凝血检测方法检测ACT、凝血酶原时间（PT）、激活部分凝血活酶时间（APTT）、纤维蛋白原定量（FIB）和血小板计数（PLT）。结果（1）Sonoclot ACT、CR和PF三项指标在CBP前无明显变化，但在CPB后显著升高（P〈0．05）；（2）常规凝血检测的PT、APTT、FIB以及PLT的值CPB前无明显变化，但在CPB后显著升高（P〈0．05）；（3）患者术前、CPB前以及CPB后，采用Sonoclot凝血及血小板功能分析仪检测的ACT值同常规凝血检测的ACT值存在明显相关。结论Sonoclot凝血及血小板功能分析仪可较为准确全面地反映患者围CPB期间的凝血功能，临床上完全可以替代常规凝血监测。Objective To explore Sonoclot clinic value observing coagulation and platelet function in 135 cardiopulmonary bypass surgery. Methods 135 cases of cardiopulmonary bypass surgery were taken venous blood before anesthesia, before CPB and protamine administration, respectively. The Sonoclot coagulation and platelet function analysis appliance detected ACT, CR and PF. Meanwhile, the ACT, PT, APTT, FIB and PLT were detected using routine methods. Results The ACT, CR and PF were markedly increased after CPB （P〈0.05） using Sonoclot. And also the ACT, PT, APTT, FIB and PLT were markedly increased after CPB （P 〈 0. 05 ） using routine methods. And the ACT value between two methods exited positive correlation. Condusion Sonoclot detecting coagulation and platelet function can replace routine methods.

关 键 词：SONOCLOT分析仪 凝血功能 体外循环 

分 类 号：R65[医药卫生—外科学]