研究MRI分子影像学发展的必备条件  

Key Points of Study for MR Molecular Image

作　　者：张贵祥[1] 赵京龙[1] 张峰[1] 李康安[1] 权启萌[1] 

机构地区：[1]上海交通大学附属第一人民医院放射科,上海200080

出　　处：《中国医疗器械信息》2008年第5期18-20,32,共4页China Medical Device Information

基　　金：国家自然基金(30571781);上海市科委重点基金(07jc14032;05jc14030)

摘　　要：研究MR分子影像学必须从二方面进行,一是开发高灵敏度、高分辨率的MR设备,二是建立特异性MRI分子探针。MRI活体、无辐射、无损伤的优势必将成为未来分子影像学和最具发展前景的设备。MRI分子探针必须具备生物学兼容性,能够在人体内参与正常生理代谢过程,不影响生理功能,对人体没有任何伤害,包括本身和遗传、致畸;必须能够克服体内生理屏障,如血脑屏障、血管壁、细胞膜等。靶分子结合必须具有高度的灵敏度、特异性,容易解离,方法简单,容易成像,便于观察和监测。Two aspects must be considered when studying MR molecular imaging： One is to develop supper sensitivity and high resolution MR equipment. The other is to develop the specific MRI molecular target probe in vivo. As with the privilege of no radiation, no harming to patients, MRI should be the most promise medical molecular imaging modality in the future. The MRI molecular probe must be biocompatible, which can participate the normal biologic progress in human body, with no side effects, especially in genetic, It must also overcome the biologic barrier, such as BBB, vascular wall, cell membrane, et al. The conjugation of the molecular target must be high sensitivity and specificity, which can be easily detached, with simple method to use and image. Molecular Image, Magnetic Resonance hnage, Probe, Disease

关 键 词：分子影像学 MRI 探针 疾病 

分 类 号：R445.2[医药卫生—影像医学与核医学]