格尔德霉素生物合成与结构改良研究进展  

Advance in Biosynthesis and Structure Reformation of Geldanamycin

作　　者：尹敏[1] 徐丽华[1] 鲁涛[1] 

机构地区：[1]云南大学微生物研究所,云南昆明650091

出　　处：《微生物学杂志》2008年第2期52-56,共5页Journal of Microbiology

基　　金：国家自然科学基金项目(30760096);云南省自然科学基金项目(2006C0009M)

摘　　要：格尔德霉素是以Hsp90为靶目标的安莎类抗生素,具有多种生物活性。其抗肿瘤活性使其成为目前肿瘤治疗领域的研究热点。综述了格尔德霉素生物合成及结构改良研究进展,并对其作为新型抗肿瘤药物的未来发展方向进行了讨论。Geldanamycin, being a kind of ansamycin antibiotics that takes heat shock protein Hsp 90 as targets possesses multiple bioactivities. Its anti-tumor activity has made it to become a hot research spot in the field of tumor therapeutics. Research progress on its biosynthesis and structure reformation as well as regarding it as future development direction of new type antitumor medicine was summarized in this naner.

关 键 词：格尔德霉素 生物合成 结构改良 

分 类 号：Q93[生物学—微生物学]