芪蛭胶囊对四氯化碳致小鼠急性肝损伤保护作用的研究  

EXPERIMENTAL STUDY ON QIZHI CAPSULE PROTECTION TO ACUTE HEPATIC INJURY INDUCED BY CCL_4 IN MICE

作　　者：石自刚[1] 任世存[1] 胥瑾[2] 

机构地区：[1]青海大学医学院 [2]中山大学护理学院

出　　处：《青海医学院学报》2008年第1期33-35,共3页Journal of Qinghai Medical College

摘　　要：目的研究芪蛭胶囊对四氯化碳(CCl4)所致小鼠急性肝损伤的保护作用。方法采用0.2%CCl4液体石蜡灌胃制作CCl4小鼠急性肝损伤模型。通过检测血清谷丙转氨酶(ALT)、谷草转氨酶(AST)、肿瘤坏死因子-α(TNF-α)、总蛋白(TP)和白蛋白(ALB)水平,探讨芪蛭胶囊对CCl4致小鼠急性肝损伤的保护作用。结果模型组与空白组比较,血清ALT、AST明显增高(P<0.01);芪蛭胶囊组与模型组比较,血清ALT、AST、TNF-α明显降低(P<0.01)。结论芪蛭胶囊对CCl4所致小鼠急性肝损伤有一定的保护作用。Objective To investigate the protective effects of Qizhi capsule against acute hepatic injury induced by CCl4 in mice.Methods Acute hepatic injury model was induced by intragastric administration of 0.2% CCl4 paroleine.To explore the roles of Qizhi capsule against acute hepatic injury induced by CCl4 in mice,by observe the change of blood serum alanine aminotransferase（ALT）、aspartate aminotransferase（AST）、tumor necrosis factor-α（TNF-α）、total protein（TP）and albumin（ALB） Results The serum ALT,AST,TNF-α in mice in model group were increased significantly compared with control group（P〈0.01）.The serum ALT,AST,TNF-α in Qizhi capsule group were decreased significantly compared with model group（P〈0.01）.Conclusion Qizhi capsule have an extended protection effect to the acute hepatic injury induced by CCl4 in mice.

关 键 词：芪蛭胶囊 四氯化碳 急性肝损伤 实验研究 

分 类 号：R944.5[医药卫生—药剂学]