脂质体对抗癌药氨甲喋呤包裹的研究  

Encapsulation of antitumor drug methotrexate in liposome vesicles

作　　者：徐波[1] 孙祺薰[1] 张年宝[1] 谢炳华[1] 张炯[1] 

机构地区：[1]中国科学院上海原子核研究所

出　　处：《核技术》1990年第5期317-320,共4页Nuclear Techniques

摘　　要：研制了包裹抗癌药氨甲喋呤(MTX)的脂质体。MTX用氚离子束标记法进行氚标记,经薄层层析制备得到纯的~3H-MTX,比活性为1.19GBq/mmol,放化纯度>95％。以~3H-MTX为示踪剂研究脂质体在各种制备条件下对MTX的包裹率,其值可达21—53％。Liposome vesicles containing antitumor drug mehotrexate (MTX) were prepared. MTX was labelled by the tritium ion beam method. After purification by TLC, the specific radioactivity of 3H-MTX was 1.19GBq/mmol with radioehetnical purity over 95%. Under various forming conditions of liposome vesicles, the efficiency of encapsulation was 21-53 %.

关 键 词：抗癌药 脂质体 氚离子束 标记法 

分 类 号：R979.1[医药卫生—药品]