舒经玫瑰胶囊对小鼠原发性痛经血浆血栓素B_2、6-酮-前列腺素F_(1α)的影响  

Effect of Red Rose Capsule for Releasing the Dysmenorrhea on Plasma Thromboxane B_2 and 6-Keto-Prostaglandin F_(1α) of Primary Dysmenorrhea Mice

作　　者：王昕[1] 姚凝[1] 刘健鸿[1] 裴培田[1] 

机构地区：[1]甘肃中医学院,甘肃兰州730000

出　　处：《中国中医药信息杂志》2008年第6期41-42,共2页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：甘肃省教育厅资助(017Q-05)

摘　　要：目的探讨舒经玫瑰胶囊对小鼠原发性痛经的保护作用。方法取体重24～26 g未孕健康小鼠64只,随机分4组:生理盐水组、舒经玫瑰胶囊小剂量组(0.8 g/25 g)、舒经玫瑰胶囊大剂量组(8 g/25 g)、月月舒对照组(50 mg/25 g),以小鼠血浆中血栓素B2(TXB2)、6-酮-前列腺素F1α(6-Keto-PGF1α)为指标进行实验观察。结果舒经玫瑰胶囊对原发性痛经小鼠血浆中的6-Keto-PGF1α升高与TXB2的降低有显著作用(P<0.01)。结论舒经玫瑰胶囊通过对TXB2及6-Keto-PGF1α含量的影响,对原发性痛经有保护作用。Objective To approach the protective actions of Red Rose Capsule for Releasing the Dysmenorrhea （RRC） on the mice of primary dysmenorrhea. Method Sixty four health rats with the similar menstrual cycle were divided into four groups - NS group, RRC low dose group, RRC high dose group and Yueyueshu group. The indexes of TXB2 and 6-Keto-PGF1α in plasma were observed. Result RRC had significant effect on increasing 6-Keto-PGF1α and decreasing TXB2 in plasma of primary dysmenorrhea mice. Conclusion RRC has protective action against primary dysmenorrhea by influencing the content of TXB2 and 6-Keto-PGF1α.

关 键 词：舒经玫瑰胶囊 原发性痛经:血栓素B2 6-酮-前列腺素F1α 小鼠 

分 类 号：R285.5[医药卫生—中药学]