肾上腺糖皮质激素与生物钟基因表达调控的相关研究进展  

Advances in interactions between glucocorticoid hormones and circadian gene expression

作　　者：倪银华[1] 吴涛[1] 王露[1] 夏李群[1] 张丹萍[1] 傅正伟[1] 

机构地区：[1]浙江工业大学生物与环境工程学院,杭州310032

出　　处：《遗传》2008年第2期135-141,共7页Hereditas（Beijing)

基　　金：浙江省自然科学基金(编号:Y204240);浙江工业大学校级科研项目资助基金(编号:20060016);浙江省新苗人才计划项目(编号:2007G60G2020059);浙江工业大学生物化工重中之重学科开放基金资助项目(编号:20050106)资助~~

摘　　要：由生物体内源性生物钟所产生的昼夜节律是近年来生命科学的研究热点之一。哺乳动物中的昼夜节律系统由位于下丘脑SCN核内的主钟和位于多数外周细胞中的子钟组成。生物钟基因及其编码的蛋白质组成反馈回路,维持振荡系统持续进行并与环境周期保持同步。光照和食物是生物钟重要的授时因子,光照刺激能引起肾上腺中基因表达变化以及糖皮质激素的分泌,而肾上腺糖皮质激素能减缓由食物因子引起的外周生物钟时相的移动。可见,肾上腺糖皮质激素与生物钟有着非常密切的关系。文章综述了两者的相互影响并对今后的研究方向做了展望。Circadian rhythm, which is internally generated by cell autonomous biological clocks, has been greatly concerned in recent years. This circadian system in mammals is composed of a master pacemaker in the suprachiasmatic nucleus （SCN） of the hypothalamus and slave docks in most peripheral cell types. The clock genes and their coding proteins compose the feedback loops of the circadian system. Light and food are two major Zeitgebers to synchronize circadian docks. Light can induce clock genes expression and glucocorticoids release in the adrenal gland, while glucocorticoids can slow down the food-induced phase-shifting of peripheral circadian oscillators, suggesting that a close relationships may exist between glucocorticoids and the circadian gene expression. This article briefly reviews the recent progress in the interactions between them and suggests the direction of future researches.

关 键 词：糖皮质激素 肾上腺 生物钟 生物节律 

分 类 号：Q3[生物学—遗传学]